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- Title
Tricin isolated from Allium atroviolaceum potentiated the effect of docetaxel on PC3 cell proliferation: role of miR-21.
- Authors
Ghasemi, Sorayya; Lorigooini, Zahra; Wibowo, JokoPriyanto; Amini-khoei, Hossein
- Abstract
For more effectiveness and overcoming the drug resistance Chemotherapy agents, the combination treatment is raised. Flavonoids with different anti-cancer effects are an appropriate choice as lead compounds. Over expressed MiR-21 in prostate cancer is associated with metastasis and drug resistance to chemotherapy with Docetaxel. In this study, the anticancer effect of 4′, 5, 7-Trihydroxy-3′, 5′-dimethoxyflavone (Tricin) was investigated with Docetaxel on PC3 cell line. Tricin was initially isolated from the Allium atroviolaceum by column chromatography and recrystallization method. The chemical structure of isolate was elucidated by spectroscopic techniques. IC50 of Tricin and Docetaxel were assessed 117.5 ± 4.4 μM and 0.1 ± 0.02 nM by MTT assay, respectively. Analysis of results indicates the synergistic effect of combination therapy on decreased proliferation. MiR-21 in treated cells with Tricin significantly decreased compared to control cells. So, Tricin can be effective in the reduction of metastasis and drug resistance of Docetaxel.
- Subjects
DOCETAXEL; PROSTATE cancer treatment; DRUG resistance; CANCER chemotherapy; CELL proliferation
- Publication
Natural Product Research, 2019, Vol 33, Issue 12, p1828
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1437439