Title: Acetylcholinesterase inhibitory active metabolites from the endophytic fungus Colletotrichum sp. YMF432.
Authors: Li, Zhe; Ma, Ni; Zhao, Pei-Ji
Abstract: An endophytic fungus, Chaetomium sp. YMF432, was isolated from Huperzia serrata (Thunb. ex Murray) Trev. and subjected to phytochemical investigation based on its special environment. From the extracts of fermentation solid of strain YMF 432, eight compounds including 1-O-methylemodin (1), 5-methoxy-2-methyl-3-tricosyl-1,4-benzoquinone (2), 4,8-dihydroxy-1-tetralone (3), (3β,5α,6α, 22E)-3-hydroxy-5,6-epoxy-7-one-8(14),22-dien-ergosta (4), ergosta-4,6,8(14),22-tetraen-3-one (5), β-sitostenone (6), β-sitosterol (7) and (22E,24R)-ergosta-5,7,22 -trien-3β-ol (8) were obtained. Their structures were elucidated on the basis of their spectroscopic data. These compounds were evaluated for acetylcholinesterase inhibitory activities in vitro. Compounds 1, 2, and 4 showed moderate acetylcholinesterase inhibitory activities (IC50 from 37.7 ± 1.5 to 370.0 ± 2.9 μM).
Subjects: METABOLITES; COLLETOTRICHUM; ACETYLCHOLINESTERASE inhibitors; PHYTOCHEMICALS; FERMENTATION; BENZOQUINONES
Publication: Natural Product Research, 2019, Vol 33, Issue 12, p1794
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786419.2018.1434648

Acetylcholinesterase inhibitory active metabolites from the endophytic fungus Colletotrichum sp. YMF432.

Li, Zhe; Ma, Ni; Zhao, Pei-Ji