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- Title
Acetylcholinesterase inhibitory active metabolites from the endophytic fungus Colletotrichum sp. YMF432.
- Authors
Li, Zhe; Ma, Ni; Zhao, Pei-Ji
- Abstract
An endophytic fungus, Chaetomium sp. YMF432, was isolated from Huperzia serrata (Thunb. ex Murray) Trev. and subjected to phytochemical investigation based on its special environment. From the extracts of fermentation solid of strain YMF 432, eight compounds including 1-O-methylemodin (1), 5-methoxy-2-methyl-3-tricosyl-1,4-benzoquinone (2), 4,8-dihydroxy-1-tetralone (3), (3β,5α,6α, 22E)-3-hydroxy-5,6-epoxy-7-one-8(14),22-dien-ergosta (4), ergosta-4,6,8(14),22-tetraen-3-one (5), β-sitostenone (6), β-sitosterol (7) and (22E,24R)-ergosta-5,7,22 -trien-3β-ol (8) were obtained. Their structures were elucidated on the basis of their spectroscopic data. These compounds were evaluated for acetylcholinesterase inhibitory activities in vitro. Compounds 1, 2, and 4 showed moderate acetylcholinesterase inhibitory activities (IC50 from 37.7 ± 1.5 to 370.0 ± 2.9 μM).
- Subjects
METABOLITES; COLLETOTRICHUM; ACETYLCHOLINESTERASE inhibitors; PHYTOCHEMICALS; FERMENTATION; BENZOQUINONES
- Publication
Natural Product Research, 2019, Vol 33, Issue 12, p1794
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1434648