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- Title
A new coumarin from Juglans mandshurica Maxim induce apoptosis in hepatocarcinoma cells.
- Authors
Lou, Li-Li; Zhao, Peng; Cheng, Zhuo-Yang; Guo, Rui; Yao, Guo-Dong; Wang, Xiao-Bo; Huang, Xiao-Xiao; Song, Shao-Jiang
- Abstract
In this study, a new coumarin, juglansoside C (1) was isolated from the bark of Juglans mandshurica. Its chemical structure was identified by comprehensive spectroscopic analyses. The in vitro cytotoxicity assay showed that 1 exhibited moderate cytotoxicity against human hepatocellular carcinoma Hep3B cells with an IC50 value of 70.9 μM. Furthermore, Annexin V-FITC/PI staining assay indicated that 1 markedly induced apoptosis in Hep3B cells.
- Subjects
COUMARINS; WALNUT varieties; APOPTOSIS; LIVER cancer; CELL-mediated cytotoxicity
- Publication
Natural Product Research, 2019, Vol 33, Issue 12, p1791
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1434646