Results
Title

A new coumarin from Juglans mandshurica Maxim induce apoptosis in hepatocarcinoma cells.

Authors

Lou, Li-Li; Zhao, Peng; Cheng, Zhuo-Yang; Guo, Rui; Yao, Guo-Dong; Wang, Xiao-Bo; Huang, Xiao-Xiao; Song, Shao-Jiang

Abstract

In this study, a new coumarin, juglansoside C (1) was isolated from the bark of Juglans mandshurica. Its chemical structure was identified by comprehensive spectroscopic analyses. The in vitro cytotoxicity assay showed that 1 exhibited moderate cytotoxicity against human hepatocellular carcinoma Hep3B cells with an IC50 value of 70.9 μM. Furthermore, Annexin V-FITC/PI staining assay indicated that 1 markedly induced apoptosis in Hep3B cells.

Subjects

COUMARINS; WALNUT varieties; APOPTOSIS; LIVER cancer; CELL-mediated cytotoxicity

Publication

Natural Product Research, 2019, Vol 33, Issue 12, p1791

ISSN

1478-6419

Publication type

Academic Journal

DOI

10.1080/14786419.2018.1434646