Title: Polygonatone H, a new homoisoflavanone with cytotoxicity from Polygonatum Cyrtonema Hua.
Authors: Wang, Wenxiang; Dabu, Xilatu; He, Juan; Yang, Huixiang; Yang, Shengchao; Chen, Junwen; Fan, Wei; Zhang, Guanghui; Cai, Jinlong; Ai, Honglian; Hai, Meirong
Abstract: A new homoisoflavonoid, (3R)-5,7-dihydroxy-6-methyl-3-(2′-hydroxy-4′-methoxybenzyl)-chroman-4-one (1), namely polygonatone H, in addition to fourteen known homoisoflavones (2–15) were isolated from the rhizome of Polygonatum Cyrtonema Hua. The structures were identified with the aid of 1D/2D NMR spectroscopic technologies. Compounds 2, 6, 8, 10, 11, 13, and 15 were isolated from P. Cyrtonema for the first time. Compound 1 showed cytotoxicities to human cancer cell lines with IC50 values to comparable those of cisplatin.
Subjects: FLAVANONES; SOLOMON'S seal; CELL-mediated cytotoxicity; CISPLATIN; CANCER cells
Publication: Natural Product Research, 2019, Vol 33, Issue 12, p1727
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786419.2018.1434645

Polygonatone H, a new homoisoflavanone with cytotoxicity from Polygonatum Cyrtonema Hua.

Wang, Wenxiang; Dabu, Xilatu; He, Juan; Yang, Huixiang; Yang, Shengchao; Chen, Junwen; Fan, Wei; Zhang, Guanghui; Cai, Jinlong; Ai, Honglian; Hai, Meirong