Results
Title

Report of in vitro antileishmanial properties of Iberian macroalgae.

Authors

Bruno de Sousa, Carolina; Lago, João Henrique G.; Macridachis, Jorge; Oliveira, Marta; Brito, Luis; Vizetto-Duarte, Catarina; Florindo, Cláudia; Hendrickx, Sarah; Maes, Louis; Morais, Thiago; Uemi, Miriam; Neto, Luís; Dionísio, Lídia; Cortes, Sofia; Barreira, Luísa; Custódio, Luísa; Alberício, Fernando; Campino, Lenea; Varela, João

Abstract

Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8–101.8 μg/mL) inducing strong morphological alterations in the parasites. Hexane extracts of C. baccata and C. barbata were also active against intracellular amastigotes (IC50 5.1 and 6.8 μg/mL, respectively). Fatty acids, triacylglycerols, carotenoids, steroids and meroterpenoids were detected by nuclear magnetic resonance (NMR), and gas chromatography in the Cystoseira extracts. These results suggest that Cystoseira macroalgae contain compounds with antileishmanial activity, which could be explored as scaffolds to the development of novel sources of antiparasitic derivatives.

Subjects

ALGAE; LEISHMANIA infantum; ANTIPARASITIC agents; PROMASTIGOTE; IN vitro studies

Publication

Natural Product Research, 2019, Vol 33, Issue 12, p1778

ISSN

1478-6419

Publication type

Academic Journal

DOI

10.1080/14786419.2018.1434637