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- Title
Furylhydroquinones and miscellaneous compounds from the roots of Lithospermum erythrorhizon and their anti-inflammatory effect in HaCaT cells.
- Authors
Ahn, Jongmin; Chae, Hee-Sung; Chin, Young-Won; Kim, Jinwoong
- Abstract
One new furylhydroquinone derivative (1) and seven known compounds (2–8) were isolated from the roots of Lithospermum erythrorhizon Sieb. et Zucc (Boraginaceae). The structure of 1 was elucidated by extensive spectroscopic methods using NMR and MS. The absolute configuration of shikonofuran J (1) was unambiguously determined by aid of comparison experimental ECD with predicted ECD spectra. All the isolates were tested for their inhibitory activities against IL-6 production in HaCaT cells stimulated by tumor necrosis factor (TNF)-α. It was found that gracicleistanthoside (5) and uridine (7) remarkably down-regulated the TNF-α-induced synthesis of interleukin-6 (IL-6), a pro-inflammatory cytokine associated with cutaneous inflammation, in HaCaT cells.
- Subjects
LITHOSPERMUM; ANTI-inflammatory agents; NUCLEAR magnetic resonance spectroscopy; INTERLEUKIN-6; INFLAMMATION
- Publication
Natural Product Research, 2019, Vol 33, Issue 12, p1691
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1431632