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- Title
Antioxidant and anti-proliferative properties of extracts from heterotrophic cultures of Galdieria sulphuraria.
- Authors
Bottone, Claudia; Camerlingo, Rosa; Miceli, Roberta; Salbitani, Giovanna; Sessa, Giuseppe; Pirozzi, Giuseppe; Carfagna, Simona
- Abstract
This study explores the possibility to use the extremophilic microalga Galdieria sulphuraria (strain 064) as a source of natural biomolecules with beneficial and protective effects on human health. Galdieria was cultivated in heterotrophy conditions and cells extracts for their antioxidant and anti-proliferative properties were tested. Galdieria extracts showed high antioxidant power tested through ABTS assay and revealed high glutathione and phycocyanin contents. Based on Annexin-V FITC/propidium iodide and MTT analysis, algae extracts inhibited the proliferation of human adenocarcinoma A549 cells (51.2% inhibition) through the induction of apoptosis without cell cycle arrest. Besides, cytotoxicity and cytometry assays showed a positive pro-apoptotic mechanism. On these bases, we suggest that G. sulphuraria from heterotrophic culture, for its therapeutic potential, could be considered a good candidate for further studies with the aim to isolate bioactive anti-cancer molecules.
- Subjects
ANTIOXIDANTS; CYANIDIUM caldarium; GLUTATHIONE; PHYCOCYANIN; PROPIDIUM iodide
- Publication
Natural Product Research, 2019, Vol 33, Issue 11, p1659
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1425853