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- Title
Trixis angustifolia hexanic extract displays synergistic antibacterial activity against M. tuberculosis.
- Authors
Sánchez-Chávez, Anahí C.; Salazar-Gómez, Anuar; Zepeda-Vallejo, L. Gerardo; Hernández de Jesús, María de L.; Quintos-Escalante, Manuel; Vargas-Díaz, Ma. Elena; Luna-Herrera, Julieta
- Abstract
A phytochemical and antibacterial study of Trixisangustifolia, a species endemic to Mexico, was performed allowing the isolation of six flavones. The minimal inhibitory concentration (MIC) of the hexanic extract, against Mycobacterium tuberculosis H37Rv was 25 μg/mL. The hexanic extract caused a significant inhibition of intracellular mycobacterial growth at 12.5 μg/mL. The biodirected assay of hexane extract enabled the detection of an active fraction (AF) against M. tuberculosis (MIC = 12.5 μg/mL), and a major flavone 1 (pebrellin) with no antimycobacterial activity (MIC > 200 μg/mL). A subsequent combination antimicrobial assay showed a synergistic antimycobacterial effect of AF in combination with pebrellin; the results of the synergistic activity suggest that the antimycobacterial activity found in T. angustifolia is due to the combined action of diverse metabolites present in the plant.
- Subjects
MYCOBACTERIUM tuberculosis; PHYTOCHEMICALS; ANTIBACTERIAL agents; FLAVONES; METABOLITES
- Publication
Natural Product Research, 2019, Vol 33, Issue 10, p1477
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2017.1416381