Results
Title

Trixis angustifolia hexanic extract displays synergistic antibacterial activity against M. tuberculosis.

Authors

Sánchez-Chávez, Anahí C.; Salazar-Gómez, Anuar; Zepeda-Vallejo, L. Gerardo; Hernández de Jesús, María de L.; Quintos-Escalante, Manuel; Vargas-Díaz, Ma. Elena; Luna-Herrera, Julieta

Abstract

A phytochemical and antibacterial study of Trixisangustifolia, a species endemic to Mexico, was performed allowing the isolation of six flavones. The minimal inhibitory concentration (MIC) of the hexanic extract, against Mycobacterium tuberculosis H37Rv was 25 μg/mL. The hexanic extract caused a significant inhibition of intracellular mycobacterial growth at 12.5 μg/mL. The biodirected assay of hexane extract enabled the detection of an active fraction (AF) against M. tuberculosis (MIC = 12.5 μg/mL), and a major flavone 1 (pebrellin) with no antimycobacterial activity (MIC > 200 μg/mL). A subsequent combination antimicrobial assay showed a synergistic antimycobacterial effect of AF in combination with pebrellin; the results of the synergistic activity suggest that the antimycobacterial activity found in T. angustifolia is due to the combined action of diverse metabolites present in the plant.

Subjects

MYCOBACTERIUM tuberculosis; PHYTOCHEMICALS; ANTIBACTERIAL agents; FLAVONES; METABOLITES

Publication

Natural Product Research, 2019, Vol 33, Issue 10, p1477

ISSN

1478-6419

Publication type

Academic Journal

DOI

10.1080/14786419.2017.1416381