New coumarin from the roots of Prangos pabularia.

Numonov, Sodik; Bobakulov, Khayrulla; Numonova, Mukhabbat; Sharopov, Farukh; Setzer, William N.; Khalilov, Qosimjon; Begmatov, Nurmirza; Habasi, Maidina; Aisa, Haji Akber

The new coumarin 1, yuganin A (7-methoxy-8-((1S,2S)-1,2,3-trihydroxy-3-methylbutyl)-2H-chromen-2-one) along with nine known coumarins, heraclenol 3′-O-β-D-glucopyranoside (2), oxypeucedanin hydrate 3′-O-β-D-glucopyranoside (3), heraclenol (4), oxypeucedanin hydrate (5), osthole (6), oxypeucedanin (7), heraclenin (8), isoimperatorin (9), imperatorin (10) and the disaccharide sucrose (11), have been isolated from the roots of Prangos pabularia, and the structures of these isolated compounds were elucidated by spectroscopic means, especially, UV, HR-ESIMS, and 1D and 2D NMR spectroscopy. Furthermore, the anti-melanogenic effect of yuganin A and its inhibitory effect on B16 cells were evaluated. Yuganin A may be useful in the treatment of hyperpigmentation and as a skin-whitening agent in the cosmetics industry.

Natural Product Research, 2018, Vol 32, Issue 19, p2325

1478-6419

Academic Journal

10.1080/14786419.2017.1413558