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- Title
New coumarin from the roots of Prangos pabularia.
- Authors
Numonov, Sodik; Bobakulov, Khayrulla; Numonova, Mukhabbat; Sharopov, Farukh; Setzer, William N.; Khalilov, Qosimjon; Begmatov, Nurmirza; Habasi, Maidina; Aisa, Haji Akber
- Abstract
The new coumarin 1, yuganin A (7-methoxy-8-((1S,2S)-1,2,3-trihydroxy-3-methylbutyl)-2H-chromen-2-one) along with nine known coumarins, heraclenol 3′-O-β-D-glucopyranoside (2), oxypeucedanin hydrate 3′-O-β-D-glucopyranoside (3), heraclenol (4), oxypeucedanin hydrate (5), osthole (6), oxypeucedanin (7), heraclenin (8), isoimperatorin (9), imperatorin (10) and the disaccharide sucrose (11), have been isolated from the roots of Prangos pabularia, and the structures of these isolated compounds were elucidated by spectroscopic means, especially, UV, HR-ESIMS, and 1D and 2D NMR spectroscopy. Furthermore, the anti-melanogenic effect of yuganin A and its inhibitory effect on B16 cells were evaluated. Yuganin A may be useful in the treatment of hyperpigmentation and as a skin-whitening agent in the cosmetics industry.
- Publication
Natural Product Research, 2018, Vol 32, Issue 19, p2325
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2017.1413558