A new C-glycosyl flavone and a new neolignan glycoside from Passiflora edulis Sims peel.

Hu, Yue; Jiao, Lin; Jiang, Min-Hong; Yin, Sheng; Dong, Pan; Zhao, Zhi-Min; Yang, De-Po; Ho, Pei-Tsai; Wang, Dong-Mei

A new C-glycosyl flavone, Chrysin-8-C-(2″-O-β-6-deoxy-glucopyranosyl)-β-D-glucopyranoside (1), a new neolignan glycoside, citrusin G (2), as well as 15 known compounds (3-17) were isolated from the peel of Passiflora edulis Sims. The structure determinations were primarily based on comprehensive spectroscopic analyses, and the absolute configuration of 2 were unequivocally determined by the CD experiment and chemical transformation. Compound 1 represents the rare examples of the flavonoid featuring a deoxy glucose sugar moiety. Compounds 5, 7 and 9 exhibited moderate inhibitory effects on nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells, with IC50 values of 34.92, 16.12 and 26.67 μM, respectively.

Natural Product Research, 2018, Vol 32, Issue 19, p2312

1478-6419

Academic Journal

10.1080/14786419.2017.1410809