A new amino amidine derivative from the wood-decaying fungus Xylaria cf. cubensis SWUF08-86.

Sawadsitang, Sasiphimol; Suwannasai, Nuttika; Mongkolthanaruk, Wiyada; Ahmadi, Peni; McCloskey, Sirirath

The secondary metabolites of Xylaria cf. cubensis SWUF08-86 fungus were investigated, and the chromatographic separation of the crude extracts yielded seventeen compounds. The structure elucidation by spectroscopic analysis including 1D and 2D NMR and the comparison of these data with literature, along with HREIMS spectrometry, revealed one new amino amidine derivative (1), together with five known simple cyclic dipeptide analogs, diketopiperazines (2-6) and eleven other known compounds, including one hemi-cycline (10), three aromatic derivatives (11-13), one sesquiterpene (14) and three sterols (15-17). The isolated compounds were screened for anticancer and anti-pathogenic bacterial and fungal activities. Based on this work, Xylaria cf. cubensis SWUF08-86 has proven to be a diverse secondary metabolites producer.

Natural Product Research, 2018, Vol 32, Issue 19, p2260

1478-6419

Academic Journal

10.1080/14786419.2017.1405414