In vitro anti-acne activity of phytoactives from the stem bark of Artocarpus hirsutus Lam. and characterisation of pyranocycloartobiloxanthone A as a mixture of two anomers.

Nayak, Mahadeva; Nagarajan, A.; Majeed, Muhammed; Nagabhushanam, Kalyanam; Choudhury, Ambar K.

This study is aimed to isolate the phytoactives from the stem bark of Artocarpus hirsutus and evaluate their in vitro anti-acne activity. The ethanolic stem bark extract of A. hirsutus provided two major phytoactive constituents: (i) pyranocycloartobiloxanthone A, (1) and (ii) Artonine E, (2) whose structures were determined by NMR and MS spectroscopic analysis. The present study is the first to report compound 1 as a mixture of two anomers (a and β), approximately 70:30 ratio. Both compounds 1 and 2 were isolated for the first time from this plant. In vitro anti-acne activity of compounds 1 and 2 were evaluated by agar well diffusion method and the minimum inhibition was determined by broth micro dilution method. The result of antimicrobial activity (MIC = 2.0 µg/mL each) is comparable to antibiotic, Clindamycin (MIC = 0.03 µg/mL) and clearly demonstrate their potential as anti-acne agents.

Natural Product Research, 2018, Vol 32, Issue 17, p2116

1478-6419

Academic Journal

10.1080/14786419.2017.1365068