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- Title
Chemical investigation of metabolites produced by an endophytic Aspergillus sp. isolated from Limonia acidissima.
- Authors
Siriwardane, A.M.D.A.; Kumar, N. Savitri; Jayasinghe, Lalith; Fujimoto, Yoshinori
- Abstract
Endophytic fungi are considered as a good source to produce important secondary metabolites with interesting bioactivities. In a continuation of our studies towards the search for environmentally friendly bioactive compounds from Sri Lankan flora, we investigated the secondary metabolites produced by the endophytic fungi Aspergillus sp. isolated from the seeds of the popular edible fruit Limonia acidissima L. of the family Rutaceae. The pure culture of the Aspergillus sp. was grown on potato dextrose broth media. After 4 weeks fermentation, fungal media were extracted with organic solvents. Chromatographic separation of the fungal extracts over silica gel, Sephadex LH-20 and RP-HPLC furnished flavasperone (1), rubrofusarin B (2), aurasperone A (3), fonsecinone D (4) and aurasperone B (5). Compounds 1–4 showed moderate activities in brine shrimp toxicity assay. This is the first report of the 13C NMR data of compounds 4 and 5.
- Publication
Natural Product Research, 2015, Vol 29, Issue 14, p1384
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2015.1025230