Results
Title

A convenient synthesis of p-substituted 1-arylsulfonyl-pyrrolidin-2-ones.

Authors

Zareef, Muhammad; Iqbal, Rashid; Khan, Khalid M.; Zaidi, Javid H.; Zia-Ullah; Arfan, Muhammad

Abstract

A convenient and novel method of cyclisation of 4-(4-substituted-phenylsulfonamido)-butanoic acids to their corresponding p-substituted 1-arylsulfonyl-pyrrolidin-2-ones was achieved by using polyphosphate ester (PPE). The reaction times were considerably reduced, with an increase in yields, when PPE was used in combination with a catalytic amount of pyridine.

Publication

Natural Product Research, 2009, Vol 23, Issue 5, p485

ISSN

1478-6419

Publication type

Academic Journal

DOI

10.1080/14786410802090375