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Title: Natural products as templates for bioactive compound libraries: synthesis of biaryl derivatives of (±)-vasicine.
Authors: Shevyakov, Sergey V.; Davydova, Olga I.; Pershin, Dmitry G.; Krasavin, Mikhail; Kravchenko, Dmitry V.; Kiselyov, Alex; Tkachenko, Sergey E.; Ivachtchenko, Alexandre V.
Abstract: A reliable and high-yielding procedure for preparation of 7-aryl and 7-heteroaryl derivatives of (±)-vasicine in two steps from the naturally occurring material is described. This protocol broadens the chemical space for selective modifications of the vasicine tricyclic structure, thereby making it a valuable starting point for the development of novel compound libraries with potentially beneficial biological profiles.
Subjects: ARYLATION; AROMATIC amines; CHEMICALS; BIOACTIVE compounds; PLANT products
Publication: Natural Product Research, 2006, Vol 20, Issue 8, p735
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786410500247418

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Natural products as templates for bioactive compound libraries: synthesis of biaryl derivatives of (±)-vasicine.