Works matching DE "DRUG activation"

Results: 884

Systemically Injectable Enzyme-Loaded Polyion Complex Vesicles as In Vivo Nanoreactors Functioning in Tumors.

Published in:

Angewandte Chemie, 2016, v. 128, n. 2, p. 570, doi. 10.1002/ange.201508339

By:

Anraku, Yasutaka;
Kishimura, Akihiro;
Kamiya, Mako;
Tanaka, Sayaka;
Nomoto, Takahiro;
Toh, Kazuko;
Matsumoto, Yu;
Fukushima, Shigeto;
Sueyoshi, Daiki;
Kano, Mitsunobu R.;
Urano, Yasuteru;
Nishiyama, Nobuhiro;
Kataoka, Kazunori

Publication type:

Article

Simple device to monitor aerobic biotransformations by in situ 1H-NMR.

Published in:

Biotechnology Letters, 2000, v. 22, n. 14, p. 1135, doi. 10.1023/A:1005664400918

By:

Brecker, L.;
Urdl, P.;
Schmid, W.;
Griengl, H.;
Ribbons, D.W.

Publication type:

Article

Metabolic engineering of Escherichia coli to produce (2S, 3R, 4S)-4-hydroxyisoleucine.

Published in:

Applied Microbiology & Biotechnology, 2010, v. 88, n. 3, p. 719, doi. 10.1007/s00253-010-2772-3

By:

Smirnov, Sergey V.;
Kodera, Tomohiro;
Samsonova, Natalya N.;
Kotlyarova, Veronika A.;
Rushkevich, Natalya Yu;
Kivero, Alexander D.;
Sokolov, Pavel M.;
Hibi, Makoto;
Ogawa, Jun;
Shimizu, Sakayu

Publication type:

Article

The stereochemical effect of SMAP-29 and SMAP-18 on bacterial selectivity, membrane interaction and anti-inflammatory activity.

Published in:

Amino Acids, 2016, v. 48, n. 5, p. 1241, doi. 10.1007/s00726-016-2170-y

By:

Jacob, Binu;
Rajasekaran, Ganesan;
Kim, Eun;
Park, Il-Seon;
Bang, Jeong-Kyu;
Shin, Song

Publication type:

Article

The synthesis and biological testing of bacilysin analogues.

Published in:

Amino Acids, 2013, v. 45, n. 5, p. 1157, doi. 10.1007/s00726-013-1571-4

By:

Robertson, Keith;
Murphy, Cormac;
Paradisi, Francesca

Publication type:

Article

Dimerization of aurein 1.2: effects in structure, antimicrobial activity and aggregation of Cândida albicans cells.

Published in:

Amino Acids, 2013, v. 44, n. 6, p. 1521, doi. 10.1007/s00726-013-1475-3

By:

Lorenzón, E.;
Sanches, P.;
Nogueira, L.;
Bauab, T.;
Cilli, E.

Publication type:

Article

Enhanced leishmanicidal activity of cryptopeptide chimeras from the active N1 domain of bovine lactoferrin.

Published in:

Amino Acids, 2012, v. 43, n. 6, p. 2265, doi. 10.1007/s00726-012-1304-0

By:

Silva, Tânia;
Abengózar, María;
Fernández-Reyes, María;
Andreu, David;
Nazmi, Kamran;
Bolscher, Jan;
Bastos, Margarida;
Rivas, Luis

Publication type:

Article

Chemical synthesis and biological evaluation of an antimicrobial peptide gonococcal growth inhibitor.

Published in:

Amino Acids, 2012, v. 43, n. 6, p. 2279, doi. 10.1007/s00726-012-1305-z

By:

Wade, John;
Lin, Feng;
Hossain, Mohammed;
Dawson, Raymond

Publication type:

Article

Biotransformation and bioactivation reactions – 2018 literature highlights.

Published in:

Drug Metabolism Reviews, 2019, v. 51, n. 2, p. 121, doi. 10.1080/03602532.2019.1615937

By:

Khojasteh, S. Cyrus;
Bumpus, Namandjé N.;
Driscoll, James P.;
Miller, Grover P.;
Mitra, Kaushik;
Rietjens, Ivonne M. C. M.;
Zhang, Donglu;
Torres, Marcelo D. T.;
Pedron, Cibele N.;
Higashikuni, Yasutomi;
Kramer, Robin M.;
Cardoso, Marlon H.;
Oshiro, Karen G. N.;
Franco, Octávio L.;
Junior, Pedro I. Silva;
Silva, Fernanda D.;
Junior, Vani X. Oliveira;
Lu, Timothy K.;
de la Fuente-Nunez, Cesar;
Mandal, M.

Publication type:

Article

Mechanisms Regulating Human FMO3 Transcription.

Published in:

Drug Metabolism Reviews, 2007, v. 39, n. 2/3, p. 419, doi. 10.1080/03602530701498612

By:

Klick, David E.;
Hines, Ronald N.

Publication type:

Article

Abstracts.

Published in:: 2008
Publication type:: Abstract

LC-MS-Based Metabolomics in Drug Metabolism.

Published in:

Drug Metabolism Reviews, 2007, v. 39, n. 2/3, p. 581, doi. 10.1080/03602530701497804

By:

Chen, Chi;
Gonzalez, Frank J.;
Idle, Jeffrey R.

Publication type:

Article

225. COMPARATIVE STUDY ON THE BIOACTIVATION OF Te-PHENYL-L-TELLUROCYSTEINE, Se-PHENYL-L-SELENOCYSTEINE, AND S-PHENYL-L-CYSTEINE.

Published in:: 2003
Publication type:: Abstract

97. BIOTRANSFORMATION OF ZAFIRLUKAST BY CYTOCHROME P450 3A4.

Published in:: 2003
Publication type:: Abstract

56. BIOANALYTICAL STRATEGY FOR XENOBIOTIC DETECTION AND IDENTIFICATION FOR IN VITRO BIOLOGICAL SAMPLES USING LC-MS/MS.

Published in:: 2003
Publication type:: Abstract

53. A FULLY AUTOMATED CHIP BASED NANOELECTROSPRAY MS/MS METHOD FOR QUANTITATIVE ANALYSIS OF CACO-2 SAMPLES.

Published in:: 2003
Publication type:: Abstract

45. UNDERSTANDING AND PREDICTING DRUG METABOLISM IN SILICO.

Published in:: 2003
Publication type:: Abstract

44. EVALUATION OF IN-VITRO DRUG DRUG INTERACTION DATA USING PBPK MODELS.

Published in:: 2003
Publication type:: Abstract

43. PROGRESS TOWARDS PREDICTION OF HUMAN PHARMACOKINETIC PARAMETERS FROM IN VITRO TECHNOLOGIES.

Published in:: 2003
Publication type:: Abstract

42. DIVERSITY OF MECHANISM-BASED PHARMACODYNAMIC MODELS.

Published in:: 2003
Publication type:: Abstract

28. INTEGRATING ADME PROPERTIES INTO DRUG DESIGN.

Published in:: 2003
Publication type:: Abstract

306. APPLICATION OF VIVID FLUOROGENIC SUBSTRATES FOR THE IN VITRO ASSESSMENT OF CYP2C9 1, CYP2C9 2 AND CYP2C9 3 METABOLISM.

Published in:: 2002
Publication type:: Abstract

293. DISPOSITION OF [<sup>14</sup>C]LAF237 IN RATS AND HUMANS.

Published in:: 2002
Publication type:: Abstract

297. THE RELATIVE ACTIVITY OF POLYMORPHIC CYP2D6 ALLELES IS SUBSTRATE DEPENDENDENT.

Published in:: 2002
Publication type:: Abstract

281. PHARMACOKINETICS AND METABOLISM OF LUMIRACOXIB IN HEALTHY MALE SUBJECTS.

Published in:: 2002
Publication type:: Abstract

269. ESTIMATION OF METABOLIC RATE IN HEPATOCYTES AND S9 FRACTIONS USING FEED-FORWARD ARTIFICIAL NEURAL NETWORKS.

Published in:: 2002
Publication type:: Abstract

278. TIME DEPENDENT STEREOSELECTIVE PHARMACOKINETICS OF VERAPAMIL AND NORVERAPAMIL IN HEALTHY VOLUNTEERS.

Published in:: 2002
Publication type:: Abstract

Effect of Different Oximes on Rat and Human Cholinesterases Inhibited by Methamidophos: A Comparative In Vitro and In Silico Study.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2012, v. 111, n. 6, p. 362, doi. 10.1111/j.1742-7843.2012.00912.x

By:

Lugokenski, Thiago Henrique;
Gubert, Priscila;
Bueno, Diones Caeran;
Nogara, Pablo Andrei;
Aquino Saraiva, Rogério;
Barcelos, Rômulo Pillon;
Carratu, Vanessa Santana;
Bresolin, Leandro;
Vargas Barbosa, Nilda Berenice;
Pereira, Maria Ester;
Rocha, João Batista Teixeira;
Soares, Félix Alexandre Antunes

Publication type:

Article

Tumor-specific biochemical nanoconversion of self-assembled peptide-conjugated paclitaxel-docetaxel-based nanoparticles.

Published in:

Nano Convergence, 2025, v. 12, n. 1, p. 1, doi. 10.1186/s40580-025-00487-0

By:

Lim, Hansol;
Lee, Jae-Hyeon;
Park, So-Hyeon;
Lee, Jun-Hyuck;
Jang, Hyesu;
Yang, Seong-Bin;
Seo, Minho;
Lee, Seokwoo;
Park, Jooho

Publication type:

Article

The role of adenoviral vectors in genetic prodrug activation therapy in prostate cancer.

Published in:

Prostate Cancer & Prostatic Diseases, 2000, v. 3, n. 1, p. S10, doi. 10.1038/sj.pcan.4500449

By:

Eaton, JD;
Clarke, IA;
Pandha, H;
Dalgleish, AG;
Kirby, RS

Publication type:

Article

Repurposing itraconazole as an anticancer agent (Review).

Published in:

Oncology Letters, 2017, v. 14, n. 2, p. 1240, doi. 10.3892/ol.2017.6325

By:

HIROSHI TSUBAMOTO;
TOMOKO UEDA;
KAYO INOUE;
KAZUKO SAKATA;
HIROAKI SHIBAHARA;
TAKASHI SONODA

Publication type:

Article

T-iDT: Tool for Identification of Drug Target in Bacteria and Validation by Mycobacterium Tuberculosis.

Published in:

In Silico Biology, 2006, v. 6, n. 6, p. 485, doi. 10.3233/isb-00260

By:

Singh, Nitesh Kumar;
Selvam, S. Mahalaxmi;
Chakravarthy, Paulsharma

Publication type:

Article

Relative importance of chemical attractiveness to parasites for susceptibility to trematode infection.

Published in:

Ecology & Evolution (20457758), 2018, v. 8, n. 17, p. 8921, doi. 10.1002/ece3.4386

By:

Langeloh, Laura;
Seppälä, Otto

Publication type:

Article

Hyperosmolarity Triggers the Warburg Effect in Chinese Hamster Ovary Cells and Reveals a Reduced Mitochondria Horsepower.

Published in:

Metabolites (2218-1989), 2021, v. 11, n. 6, p. 344, doi. 10.3390/metabo11060344

By:

da Veiga Moreira, Jorgelindo;
De Staercke, Lenny;
César Martínez-Basilio, Pablo;
Gauthier-Thibodeau, Sandrine;
Montégut, Léa;
Schwartz, Laurent;
Jolicoeur, Mario

Publication type:

Article

Synthesis, Antibacterial Evaluation, and QSAR of Caffeic Acid Derivatives.

Published in:

Journal of Chemistry, 2019, p. 1, doi. 10.1155/2019/3408315

By:

Araújo, Marianna O.;
Freire Pessoa, Hilzeth L.;
Lira, Andressa B.;
Castillo, Yunierkis P.;
de Sousa, Damião P.

Publication type:

Article

Nitraria schoberi L. hairy root culture as a source of compounds with antiviral activity against influenza virus subtypes А(H5N1) and А(H3N2).

Published in:

3 Biotech, 2018, v. 8, n. 6, p. 1, doi. 10.1007/s13205-018-1280-5

By:

Zheleznichenko, Tatiana;
Banaev, Evgenii;
Asbaganov, Sergey;
Voronkova, Maria;
Kukushkina, Tatiana;
Filippova, Ekaterina;
Mazurkova, Natalia;
Shishkina, Larisa;
Novikova, Tatyana

Publication type:

Article

Geranylgeranylacetone has anti-hepatitis C virus activity via activation of mTOR in human hepatoma cells.

Published in:

Journal of Gastroenterology, 2012, v. 47, n. 2, p. 195, doi. 10.1007/s00535-011-0481-z

By:

Takeshita, Shigeyuki;
Ichikawa, Tatsuki;
Taura, Naota;
Miyaaki, Hisamitsu;
Matsuzaki, Toshihisa;
Otani, Masashi;
Muraoka, Toru;
Akiyama, Motohisa;
Miuma, Satoshi;
Ozawa, Eisuke;
Ikeda, Masanori;
Kato, Nobuyuki;
Isomoto, Hajime;
Takeshima, Fuminao;
Nakao, Kazuhiko

Publication type:

Article

Special offer available.

Published in:: British Dental Journal, 2004, v. 196, n. 7, p. 429, doi. 10.1038/sj.bdj.4811164
Publication type:: Article

IN VITRO PROBIOTIC CHARACTERISTICS OF ENTEROCOCCUS SPECIES ISOLATED FROM RAW COW MILK.

Published in:

International Journal of Probiotics & Prebiotics, 2018, v. 13, n. 2/3, p. 117

By:

Elkenany, Rasha M.;
Elsayed, Mona M.;
Eltaysh, Rasha A.;
Zakaria, Amira I.;
El-Baz, Amira H.

Publication type:

Article

Elevated Interleukin-6 Concentration and Alterations of the Coagulation System Are Associated with the Development of Intraventricular Hemorrhage in Extremely Preterm Infants.

Published in:

Neonatology (16617800), 2012, v. 102, n. 4, p. 270, doi. 10.1159/000341266

By:

Poralla, Christine;
Hertfelder, Hans-Jörg;
Oldenburg, Johannes;
Müller, Andreas;
Bartmann, Peter;
Heep, Axel

Publication type:

Article

Colorectal Cancer Chemoprevention by S -Allyl Cysteine–Caffeic Acid Hybrids: In Vitro Biological Activity and In Silico Studies.

Published in:

Scientia Pharmaceutica, 2022, v. 90, n. 3, p. 40, doi. 10.3390/scipharm90030040

By:

Herrera-Ramirez, Angie;
Yepes-Pérez, Andres F.;
Quintero-Saumeth, Jorge;
Moreno-Quintero, Gustavo;
Naranjo, Tonny W.;
Cardona-Galeano, Wilson

Publication type:

Article

Antibacterial Activity of Ethanolic Extract of Cinnamon Bark, Honey, and Their Combination Effects against Acne-Causing Bacteria.

Published in:

Scientia Pharmaceutica, 2017, v. 85, n. 2, p. 1, doi. 10.3390/scipharm85020019

By:

Julianti, Elin;
Rajah, Kasturi K.;
Fidrianny, Irda

Publication type:

Article

Biotransformation of Artemisinin Mediated through Fungal Strains for Obtaining Derivatives with Novel Activities.

Published in:

Scientia Pharmaceutica, 2009, v. 77, n. 1, p. 87, doi. 10.3797/scipharm.0803-15

By:

Srivastava, Suchita;
Luqman, Suaib;
Fatima, Atiya;
Darokar, Mahendra P.;
Negi, Arvind S.;
Kumar, J. K.;
Shanker, K.;
Chanotiya, Chandan S.;
Tandon, Sudeep;
Khanuja, Suman P. S.

Publication type:

Article

Redistribución de grasa y alteraciones metabólicas en niños y adolescentes infectados por VIH/SIDA con tratamiento antirretroviral altamente activo.

Published in:

Boletín Médico del Hospital Infantil de México, 2009, v. 66, n. 4, p. 343

By:

Muñoz-Hernández, María Rocío;
Santos-Preciado, José Ignacio;
Pavía-Ruz, Noris

Publication type:

Article

Respuesta discordante a terapia antirretroviral altamente activa en pacientes pediátricos mexicanos infectados con VIH/SIDA.

Published in:

Boletín Médico del Hospital Infantil de México, 2009, v. 66, n. 4, p. 335

By:

Romano-Mazzotti, Luis;
Sifuentes-Vela, Claudia;
Villalobos-Acosta, Patricia;
Santos-Preciado, José Ignacio;
Pavía-Ruz, Noris

Publication type:

Article

Patrón de la enfermedad y sobrevida en niños y adolescentes infectados por VIH manejados con terapia antirretroviral altamente activa.

Published in:

Boletín Médico del Hospital Infantil de México, 2009, v. 66, n. 4, p. 314

By:

Villalobos-Acosta, Claudia Patricia;
Plascencia-Gómez, Elsy Consuelo;
Romano-Mazzotti, Luis;
Pavía-Ruz, Noris

Publication type:

Article

Anti-EGFR anchored paclitaxel loaded PLGA nanoparticles for the treatment of triple negative breast cancer. In-vitro and in-vivo anticancer activities.

Published in:

PLoS ONE, 2018, v. 13, n. 11, p. 1, doi. 10.1371/journal.pone.0206109

By:

Venugopal, Vijayan;
Krishnan, Shalini;
Palanimuthu, Vasanth Raj;
Sankarankutty, Subin;
Kalaimani, Jayaraja Kumar;
Karupiah, Sundram;
Kit, Ng Siew;
Hock, Tang Thean

Publication type:

Article

Thermodynamic and computational analyses reveal the functional roles of the galloyl group of tea catechins in molecular recognition.

Published in:

PLoS ONE, 2018, v. 13, n. 10, p. 1, doi. 10.1371/journal.pone.0204856

By:

Takahashi, Tomoya;
Nagatoishi, Satoru;
Kuroda, Daisuke;
Tsumoto, Kouhei

Publication type:

Article

Recombinant AfusinC, an anionic fungal CSαβ defensin from Aspergillus fumigatus, exhibits antimicrobial activity against gram-positive bacteria.

Published in:

PLoS ONE, 2018, v. 13, n. 10, p. 1, doi. 10.1371/journal.pone.0205509

By:

Contreras, Gabriela;
Braun, Markus Santhosh;
Schäfer, Holger;
Wink, Michael

Publication type:

Article

CYP11B1 has no role in mitotane action and metabolism in adrenocortical carcinoma cells.

Published in:

PLoS ONE, 2018, v. 13, n. 5, p. 1, doi. 10.1371/journal.pone.0196931

By:

Germano, Antonina;
Saba, Laura;
De Francia, Silvia;
Rapa, Ida;
Perotti, Paola;
Berruti, Alfredo;
Volante, Marco;
Terzolo, Massimo

Publication type:

Article