Results
Title

Enzymatic assays and molecular modeling studies of Schisandra chinensis lignans and phenolics from fruit and leaf extracts.

Authors

Mocan, Andrei; Zengin, Gokhan; Crişan, Gianina; Mollica, Adriano

Abstract

Considerable interest has been shown in natural sources and their compounds in developing new therapeutically agents for different diseases. In this framework, investigations performed on this topic play a central role for human health and drug development process.Schisandra chinensis(Turcz.) Baill is a medicinal and edible plant showing highly advantageous bioactivity and nutritional value. The main bioactive compounds from its fruits are lignans, derivatives of dibenzocyclooctadiene whereas concerning its leaves, phenolic acids, and flavonoids are dominant. The purpose of this study was to investigate the enzyme inhibitory potential on selected carbohydrate hydrolases, cholinesterases, and tyrosinase of extracts from fruits and leaves ofSchisandrain relation with their main bioactive compounds. Furthermore, the interactions between dominant compounds (schisandrol A, schisandrol B, schisandrin B, and cinnamic acid) from extracts and selected enzymes were investigated by molecular modeling and molecular dynamic studies in order to explain at a molecular level our findings.

Subjects

ENZYMATIC analysis; MOLECULAR models; SCHISANDRA chinensis; LIGNANS; PHENOLS

Publication

Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, Vol 31, p200

ISSN

1475-6366

Publication type

Academic Journal

DOI

10.1080/14756366.2016.1222585