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- Title
Applying CHW method to 2-in-1 design: gain or lose?
- Authors
Bai, Xiaofei; Deng, Qiqi
- Abstract
The 2-in-1 design allows the possibility of seamlessly expanding a phase II study to confirmatory phase III study and controls type I error without multiplicity adjustment. In this paper, we applied the CHW method to the 2-in-1 design strategy, and compared it with the unweighted conventional test statistics. It shows that when the interim decision threshold is high enough, the CHW method is slightly more powerful. Otherwise, results based on the CHW method can be difficult to interpret when the estimated treatment effects differ notably between interim and final analysis, which may be avoided by using the conventional test statistic.
- Subjects
FALSE positive error
- Publication
Journal of Biopharmaceutical Statistics, 2019, Vol 29, Issue 4, p714
- ISSN
1054-3406
- Publication type
Academic Journal
- DOI
10.1080/10543406.2019.1633656