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- Title
Cognitive function in patients with chronic lymphocytic leukemia: a cross-sectional study examining effects of disease and treatment.
- Authors
Williams, AnnaLynn M.; van Wijngaarden, Edwin; Seplaki, Christopher L.; Heckler, Charles E.; Weber, Miriam T.; Barr, Paul M.; Zent, Clive S.; Janelsins, Michelle C.
- Abstract
Cancer-related cognitive impairment (CRCI) has not been objectively assessed in chronic lymphocytic leukemia (CLL). It is currently unclear how much of CRCI is attributable to disease, treatment, or both. We used CLL as a novel model to study the differential roles of disease and treatment in CRCI. One hundred and fifty CLL patients (100 treatment-naïve and 50 chemotherapy-treated) including 84 patients with higher-risk of CLL progression completed objective neuropsychological tests. Sociodemographic-adjusted linear regression models examined cognitive outcomes in relation to risk and treatment. Higher-risk patients recalled two fewer words on a memory task (β = −1.8, 95%CI –3.3,−0.3) and took 15 s longer on an executive function task (β = 15.4, 95%CI 3.1, 27.6) than lower-risk patients, independent of treatment. Treated patients reported greater cognitive difficulties than treatment-naive patients (β = −6.1, 95%CI –10.1, −2.2) but did not perform worse on objective measures. Higher-risk patients experienced impairments in executive function and memory suggesting that disease biology contributes to CRCI independent of treatment.
- Subjects
CHRONIC lymphocytic leukemia; TREATMENT effectiveness; THERAPEUTICS; COGNITIVE ability; CANCER treatment; COGNITION disorders; CHRONIC leukemia
- Publication
Leukemia & Lymphoma, 2020, Vol 61, Issue 7, p1627
- ISSN
1042-8194
- Publication type
Academic Journal
- DOI
10.1080/10428194.2020.1728748