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Title: Synthesis of Substituted Pyrazino[5,6-b]pyrimidine and Some Indole Derivatives.
Authors: Nami, Navabeh; Hosseinzadeh, Masoumeh; Nami, Nasrin; Haghdadi, Mina
Abstract: Refluxing dimethyl acetylenedicarboxylate (DMAD) or 1,2-dibenzoylacetylene with isatin-3-thiosemicarbazone or isatin-3-thiocarbohydrazone in methanol produced 3-substituted oxindoles in good yields. Reaction of equimolecular amounts of 5,6-diamino-urasil-solfate, trans-(1R,2R)-diaminocyclohexane, and 3,4-diamino-1,2,4-triazol-5-methyl hydrochlorid with isatin in ethanol (85%) afforded tetracyclic ring systems and ring-opened products in mild reaction conditions.
Subjects: ISATIN; THIOSEMICARBAZONES; METHANOL; TRIAZOLES; CHEMICAL reactions
Publication: Phosphorus, Sulfur & Silicon & the Related Elements, 2009, Vol 184, Issue 11, p2846
ISSN: 1042-6507
Publication type: Academic Journal
DOI: 10.1080/10426500802590228

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Synthesis of Substituted Pyrazino[5,6-b]pyrimidine and Some Indole Derivatives.