Title: The Synthesis and Characterization of New Asymmetrical Dihydropyridine Derivatives Containing a 2,4-Dichloro-5-Thiazolyl Substituent.
Authors: Ghodsi, Shahram; Alipour, Eskandar; Amini, Mohsen; Miri, Ramin; Tagi-Ganji, Karim Masoud; Hosseini, Marjan; Mirkhani, Hossein; Shafiee, Abbas
Abstract: Dihydropyridines (DHP) having a heterocyclic aryl substituent at position-4 are calcium channel antagonists. In this report a new group of DHP derivatives with different esters at the C 3 and C 5 position (asymmetrical diesters) containing 2,4-dichloro-5-thiazolyl at position-4 were synthesized by a condensation reaction of alkyl, cycloalkyl, and aryl acetoacetate in the presence of ammonium acetate in a new shorter pathway. The structure of all compounds was confirmed by IR, 1 H NMR, and mass spectrometry. The calcium channel antagonist activity of compounds 6a–6f demonstrated that the compound 6a was the most active compound.
Subjects: DIHYDROPYRIDINE; HETEROCYCLIC compounds; THIAZOLES; PYRIDINE derivatives; MASS spectrometry
Publication: Phosphorus, Sulfur & Silicon & the Related Elements, 2006, Vol 181, Issue 10, p2435
ISSN: 1042-6507
Publication type: Academic Journal
DOI: 10.1080/10426500600732808

The Synthesis and Characterization of New Asymmetrical Dihydropyridine Derivatives Containing a 2,4-Dichloro-5-Thiazolyl Substituent.

Ghodsi, Shahram; Alipour, Eskandar; Amini, Mohsen; Miri, Ramin; Tagi-Ganji, Karim Masoud; Hosseini, Marjan; Mirkhani, Hossein; Shafiee, Abbas