EBSCO Logo
Connecting you to content on EBSCOhost
Results
Title

Drugs and Their Mode of Action: A Review on Sulfur-Containing Heterocyclic Compounds.

Authors

Kapoor, Kanchan; Kaur, Navneet; Sohal, Harvinder Singh; Kaur, Manvinder; Singh, Kishanpal; Kumar, Asim

Abstract

Sulfur-containing heterocyclic compounds have emerged as an important class of bioactive molecules in drug discovery owing to their diverse pharmacological activities and unique modes of action. Sulfur drugs exert their pharmacological actions primarily through their ability to interfere with microbial growth and modulate immune responses. The provided compounds showed a spectrum of heterocyclic ring structures of varying sizes, from three- to seven-membered rings, each influencing the medicinal potency of the compounds. Smaller rings, such as three- and four-membered rings, often impart unique reactivity and functional properties, potentially leading to potent pharmacological effects. Conversely, larger rings, such as six- and seven-membered rings, may offer increased structural stability and favorable interactions with biological targets, enhancing the medicinal potency of the compounds. Understanding the relationship between ring size and medicinal potency is crucial in drug design to facilitate the development of therapeutics with optimized efficacy and pharmacokinetic properties. This review provides a comprehensive overview of drugs that contain sulfur-containing heterocyclic compounds as key structural motifs, modes of action, and interactions with specific protein targets, enzymes, receptors, and cellular processes. Moreover, we highlight their potential as drug candidates for treating numerous diseases and highlight their significance in drug discovery research.

Subjects

DRUG discovery; HETEROCYCLIC compounds; DRUG target; DOSAGE forms of drugs; DRUG design

Publication

Polycyclic Aromatic Compounds, 2025, Vol 45, Issue 1, p136

ISSN

1040-6638

Publication type

Academic Journal

DOI

10.1080/10406638.2024.2392781

EBSCO Connect | Privacy policy | Terms of use | Copyright | Manage my cookies
Journals | Subjects | Sitemap
© 2025 EBSCO Industries, Inc. All rights reserved