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- Title
Total syntheses of surinone B, alatanones A-B, and trineurone A.
- Authors
Gundoju, Narayana Rao; Bokam, Ramesh; Yalavarthi, Nageswara Rao; Ponnapalli, Mangala Gowri; Buddana, Sudheer Kumar; Prakasham, R. S.
- Abstract
The total syntheses of four polyketides, surinone B (1), alatanones A-B (2-3), and trineurone A (4) were accomplished through an efficient and unified strategy via one-pot C-acylation reaction coupling 1,3-cyclohexadiones with EDC-activated acids under mild conditions. Alatanone A (2) was found to be a potent anti-microbial agent against Gram-positive and Gram-negative bacteria with MIC 31.25 μg/ml while alatanone B (3) was found to be a potent anti-fungal agent against Cladosporium cladosporioides with MIC 62.5 μg/ml compared to cycloheximide MIC 125 μg/ml. Our methodology allows performing kilogram scale of these scarce polyketides for the development of new antimicrobials.
- Subjects
PLANT chemical analysis; MACROLIDE antibiotics; ANTI-infective agents; ANTIFUNGAL agents; ANTILIPEMIC agents; ANTIPARASITIC agents; GRAM-negative bacteria; GRAM-positive bacteria; IMMUNOSUPPRESSIVE agents; PLANTS; RESEARCH funding; THERAPEUTICS
- Publication
Journal of Asian Natural Products Research, 2019, Vol 21, Issue 3, p262
- ISSN
1028-6020
- Publication type
Academic Journal
- DOI
10.1080/10286020.2018.1460362