Monoterpenes and sesquiterpenes from the marine sediment-derived fungus Eutypella scoparia FS46.

Liu, Hong-Xin; Zhang, Ling; Chen, Yu-Chan; Sun, Zhang-Hua; Pan, Qing-Ling; Li, Hao-Hua; Zhang, Wei-Min

Eutypellol A (1), the first norsesquiterpenoid of sequicarene family, as well as eutypellol B (2), a rare 7-methyl oxidized 2-carene derivative, and one new natural product 2-(2-hydroxy-4-methylcyclohex-3-enyl)propanoic acid (3), along with eight known terpenoids, were isolated from the marine sediment-derived fungusEutypella scopariaFS46 collected from the South China Sea. Their structures were established on the basis of extensive spectroscopic analysis. Compounds1–3were evaluated for their antibacterial activities againstStaphylococcus aureusand cytotoxic activities against MCF-7, NCI-H460, and SF-268 tumor cell lines.

CHINA; ANTIBIOTICS assay; ANTIBIOTICS; ANTINEOPLASTIC agents; CELL lines; CHROMATOGRAPHIC analysis; CISPLATIN; CLINICAL drug trials; FERMENTATION; FUNGI; MASS spectrometry; MOLECULAR structure; NUCLEAR magnetic resonance spectroscopy; OCEAN; RESEARCH funding; STAPHYLOCOCCUS aureus; TERPENES

Journal of Asian Natural Products Research, 2017, Vol 19, Issue 2, p145

1028-6020

Academic Journal

10.1080/10286020.2016.1189906