Two new 28-nor-oleanane-type triterpene saponins from roots of Camellia oleifera and their cytotoxic activity.

Zhang, Zi-Yu; Wu, Jiang-Ping; Gao, Bin-Bin; Ren, Hai-Tao; Liu, Yan-Li; Li, Xiao-Ran; Li, Kun-Ping; Xu, Qiong-Ming; Yang, Shi-Lin

Two new 28-nor-oleanane-type triterpene saponins, oleiferoside U (1), and oleiferoside V (2) were isolated from the 50% EtOH extract of the roots ofCamellia oleiferaC. Abel. Their structures were elucidated as camellenodiol 3β-O-β-d-galactopyranosyl-(1→2)-β-d-xylopyranosyl-(1→2)-[β-d-galactopyranosyl-(1→3)]-β-d-glucuronopyranoside and camellenodiol 3β-O-β-d-galactopyranosyl-(1→3)-β-d-xylopyranosyl-(1→2)-[β-d-galactopyranosyl-(1→3)]-β-d-glucuronopyranoside. Their chemical structures were established mainly on the basis of integrated spectroscopic techniques.In vitro, cytotoxic activities of the two new triterpene saponins were evaluated against three human tumor cell lines (A549, SMMC-7721, and MCF-7) using the MTT assay. Both of them showed a certain cytotoxic activities toward the tested cell lines and gave IC50values in the range of 45.04–63.22 μM.

Journal of Asian Natural Products Research, 2016, Vol 18, Issue 7, p669

1028-6020

Academic Journal

10.1080/10286020.2016.1158167