Title: Cytotoxic triterpenesaponins from Ilex pubescens.
Authors: Li, Ling; Feng, Li-Shi; He, Yu-Xin
Abstract: Two new triterpenesaponins, ilexsaponins G and H (1 and 2), together with six known triterpenesaponins (3–8), were isolated from the roots of Ilex pubescens. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis products. Those compounds showed inhibitory activities against two human colorectal cancer cell lines HCT 116 and HT-29.
Subjects: CHROMATOGRAPHIC analysis; ANTINEOPLASTIC agents; BIOLOGICAL assay; CELL culture; COLON tumors; GLYCOSIDES; MASS spectrometry; MOLECULAR structure; NUCLEAR magnetic resonance spectroscopy; PACLITAXEL; PHARMACEUTICAL chemistry; RECTUM tumors; RESEARCH funding; PLANT roots; TERPENES; TOXICITY testing; CYTOTOXINS; DESCRIPTIVE statistics
Publication: Journal of Asian Natural Products Research, 2014, Vol 16, Issue 8, p830
ISSN: 1028-6020
Publication type: Academic Journal
DOI: 10.1080/10286020.2014.920012

Cytotoxic triterpenesaponins from Ilex pubescens.

Li, Ling; Feng, Li-Shi; He, Yu-Xin