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Title: Two new 20α(H)-ursane-type triterpenoids from Ilex cornuta and their cytotoxic activities.
Authors: Wang, Wen-Lian; Zhou, Xi; Liu, Yan-Li; Xu, Qiong-Ming; Li, Xiao-Ran; Yang, Shi-Lin
Abstract: Two new 20α-ursane-type triterpenoids (1–2) were isolated from the roots ofIlex cornuta, along with three known triterpenoids (3–5). The structures of compounds1–2were determined as 3β, 23-dihydroxy-20α(H)-urs-12-en-28-oic acid (1), 3β,19α,23-trihydroxy-20α(H)-urs-12-en-28-oic acid 3β-O-α-l-arabinopyranoside (2), on the basis of hydrolysis and spectral evidence, including 1D- and 2D-NMR and high-resolution electrospray ionization mass spectrometry analyses. These pure isolates (1–5) were tested for their cytotoxic activities by MTT assay.
Subjects: BIOLOGICAL assay; CELL culture; GLYCOSIDES; HIGH performance liquid chromatography; MASS spectrometry; MOLECULAR structure; NUCLEAR magnetic resonance spectroscopy; RESEARCH funding; TERPENES; TOXICITY testing; PLANT extracts
Publication: Journal of Asian Natural Products Research, 2014, Vol 16, Issue 2, p175
ISSN: 1028-6020
Publication type: Academic Journal
DOI: 10.1080/10286020.2013.855725

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Two new 20α(H)-ursane-type triterpenoids from Ilex cornuta and their cytotoxic activities.