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- Title
In vitro evaluation of schistosomicidal potential of curcumin against Schistosoma japonicum.
- Authors
Chen, Yan-Qin; Xu, Qiong-Ming; Li, Xiao-Ran; Yang, Shi-Lin; Zhu-Ge, Hong-Xiang
- Abstract
Curcumin is a polyphenol derived from the dietary spice turmeric. The aim of this study was to investigate the in vitro effect of curcumin against eggs, cercariae, pre-adults, and adults of Schistosoma japonicum compared to praziquantel. After incubated by different concentration of curcumin or praziquantel in different time, the percent hatching rates of eggs, the percent dead rates of cercariae, and the number of dead worms were observed. Curcumin showed time- and dose-dependent schistosomicidal effects on every life stages of S. japonicum. In addition, curcumin exhibited an optimal activity against the adult stage with no differential sensitivity between male and female worms and decreased motor activity of these worms without tegumental alterations. The promising in vitro effects on all stages of S. japonicum warrants further evaluation for the prophylactic and therapeutic values in the early and late schistosomiasis in field trials.
- Subjects
MICROSCOPY; ANALYSIS of variance; ANIMAL experimentation; ANTHELMINTICS; HELMINTHS; ISOQUINOLINE; MOLECULAR structure; RESEARCH funding; TREMATODA; DATA analysis software; CURCUMIN; IN vitro studies; PHARMACODYNAMICS
- Publication
Journal of Asian Natural Products Research, 2012, Vol 14, Issue 11, p1064
- ISSN
1028-6020
- Publication type
Academic Journal
- DOI
10.1080/10286020.2012.708657