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- Title
Oxygen-ozone therapy for pain relief in patients with trapeziometacarpal osteoarthritis: a proof-of-concept study.
- Authors
de Sire, Alessandro; Marotta, Nicola; Sconza, Cristiano; Lippi, Lorenzo; Drago Ferrante, Vera; Respizzi, Stefano; Invernizzi, Marco; Ammendolia, Antonio
- Abstract
Purpose: Trapeziometacarpal osteoarthritis (TMC-OA) is a prevalent hand disorder affecting a growing number of people worldwide. While a multidisciplinary approach might provide additional advantages, the analgesic and anti-inflammatory role of intra-articular oxygen-ozone (O2O3) injections combined with physical therapy is still unknown. To assess the impact of a multimodal therapeutic approach combining O2O3 injections with physical therapy in patients with TMC-OA. Materials and methods: A prospective open-label study conducted in the Physical and Rehabilitation Medicine Unit of the "Renato Dulbecco" University Hospital of Catanzaro. We assessed patients with TMC-OA who had not responded to standard medical therapy. Participants received O2O3 therapy and targeted physical therapy for 4 weeks. Pain relief, muscle strength, and physical functioning were assessed at baseline and after 4, 12 and 24 weeks (respectively T0, T1, T2, and T3) Results: Seventeen patients with a mean age of 67.1 ± 6.1 years were included in the study. Short-term improvements in pain intensity were observed (T0: 6.221 ± 1.514; T1: 3.172 ± 1.1451; p 2O3 therapy was well-tolerated with no adverse effects. Conclusions: A combination of O2O3 injections and physical therapy might be considered in patients with TMC-OA. Further investigation is warranted to assess the effectiveness of O2O3 therapy in managing TMC-OA. IMPLICATIONS FOR REHABILITATION: The addition of intra-articular trapeziometacarpal O2O3 injections to physical therapy is safe and reliable for thumb osteoarthritis O2O3 injection could be considered a second-line mini-invasive approach option when simple analgesic and non-pharmacologic interventions have failed, and surgical treatment is not yet indicated O2O3 injections in combination with physical therapy may provide benefits in terms of pain relief in patients with TMC joint OA in whom previous conventional medical therapy has been unsuccessful
- Subjects
ITALY; PHYSICAL therapy; PAIN measurement; MOTOR ability; REPEATED measures design; OXYGEN; ACADEMIC medical centers; T-test (Statistics); OXYGEN therapy; FUNCTIONAL assessment; CLINICAL trials; TREATMENT effectiveness; DESCRIPTIVE statistics; INTRA-articular injections; LONGITUDINAL method; MUSCLE strength; COMBINED modality therapy; PAIN management; CARPOMETACARPAL joints; OSTEOARTHRITIS; OZONE; QUALITY of life; ANALYSIS of variance; DATA analysis software; OZONE therapy; PATIENT aftercare
- Publication
Disability & Rehabilitation, 2025, Vol 47, Issue 2, p452
- ISSN
0963-8288
- Publication type
Academic Journal
- DOI
10.1080/09638288.2024.2342491