Effects of vitamin D supplementation on metabolic parameters of women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials.

Wang, Li; Wen, Xinqiang; Lv, Shulan; Tian, Sijuan; Jiang, Yifan; Yang, Xiaofeng

The purpose of this meta-analysis was to evaluate the effects of vitamin D supplementation on metabolic parameters of women with polycystic ovary syndrome (PCOS). We performed a literature search of databases and identified randomized controlled trials (RCTs) published prior to December 2019. A meta-analysis was conducted using RevMan 5.3 and Stata 12.0 software. We compared the effects of vitamin D supplementation alone to the administration of placebos on metabolic parameters of PCOS women with vitamin D deficiency. Ten articles of RCTs were included and analyzed in this meta-analysis, which included a total of 520 PCOS women. Our meta-analysis results showed no significant effects of vitamin D supplementation on BMI (p =.43), systolic blood pressure (p =.05), diastolic blood pressure (p =.87), fasting insulin concentration (p =.86), HOMA-IR (p =.47), HDL-C (p =.76), LDL-C (p =.23) and triglyceride (p =.77). Both low dose vitamin D supplementation (<4000 IU/day) and high dose vitamin D supplementation (≥4000 IU/day) were found to significantly decreased the fasting glucose concentration (p =.01, p =.001, respectively). Vitamin D supplementation significantly decreased total cholesterol concentration (p =.03). The results of this meta-analysis suggested that vitamin D supplementation decreases fasting glucose concentration and total cholesterol concentration in PCOS women with vitamin D deficiency.

DIETARY supplements; POLYCYSTIC ovary syndrome; VITAMIN D; RANDOMIZED controlled trials; SYSTOLIC blood pressure

Gynecological Endocrinology, 2021, Vol 37, Issue 5, p446

0951-3590

Academic Journal

10.1080/09513590.2020.1813272