Comparative Study of Microbiological Profile and Management Outcomes of Acute Endophthalmitis after Microincision Vitrectomy Surgery versus Intravitreal Injections.

Kannan, Naresh Babu; Sen, Sagnik; Mishra, Chitaranjan; Lalitha, Prajna; Rameshkumar, Gunasekaran; Rajan, Renu P; Arumugam, Karthik Kumar; Ramasamy, Kim

Purpose: The aim of this study was to evaluate and compare incidence and outcomes of management of acute endophthalmitis after microincision vitrectomy surgery (MIVS) and intravitreal injections (IVIs).Methods: Medical records were retrospectively reviewed from January 2012 to December 2017, and the incidence, clinical and microbiological profiles of acute endophthalmitis were documented.Results: Of 26,332 MIVS and 24,143 IVI performed, incidence of acute endophthalmitis in MIVS group was 0.027% (1 in 3761 cases) against 0.054% (1 in 1857 cases) in IVI. Gram-positive organisms were causative in post IVI group as against gram-negative organisms in MIVS group.Conclusion: Incidence of endophthalmitis after IVI is almost twice that after MIVS. A trend toward poorer outcomes in MIVS eyes was observed. Both MIVS and IVI being pars plana procedures warrant similar kind of aseptic precautions.

INTRAVITREAL injections; ENDOPHTHALMITIS; PARS plana; VITRECTOMY; COMPARATIVE studies; SURGERY; VASCULAR endothelial growth factor antagonists; DIAGNOSIS of bacterial diseases; ANTIBIOTICS; GLUCOCORTICOIDS; RESEARCH; INJECTIONS; NEOVASCULARIZATION inhibitors; AQUEOUS humor; COMBINATION drug therapy; GRAM-negative bacteria; MICROSURGERY; VITREOUS body; RESEARCH methodology; DISEASE incidence; RETROSPECTIVE studies; EVALUATION research; TREATMENT effectiveness; EYE infections; VISUAL acuity; BACTERIAL diseases; GRAM-positive bacteria; ACUTE diseases

Ocular Immunology & Inflammation, 2021, Vol 29, Issue 5, p838

0927-3948

Academic Journal

10.1080/09273948.2019.1695858