Title: Evaluating a promising methylcellulose hydrogel for enhanced diabetic foot ulcer therapy through comprehensive preclinical studies.
Authors: Patel, Priya; Dongre, Sanika; Patel, Alkesh; Patel, Gayatri
Abstract: The present research focuses on formulating and evaluating hydrogels modified with crosslinking agents using methylcellulose to treat diabetic foot ulcers (DFU). Methylcellulose hydrogels are prepared and characterized for their crosslinking capacity through FTIR and degradation studies. The optimized hydrogel is further assessed for viscosity, gel strength, contact angle, in-vitro biodegradation, water-vapor transmission rate, anti-bacterial activity, and in-vivo efficacy. The results demonstrate that the developed hydrogel exhibits promising properties for DFU treatment, including increased wound healing percentage, improved ulcer morphology, reduced levels of proinflammatory cytokines, and enhanced tissue characteristics. These findings suggest that the novel hydrogel composition could serve as a viable alternative to existing dressings for DFU management.
Subjects: DIABETIC foot; METHYLCELLULOSE; CONTACT angle; ANTIBACTERIAL agents; WOUND healing; HYDROGELS
Publication: Journal of Biomaterials Science -- Polymer Edition, 2024, Vol 35, Issue 9, p1421
ISSN: 0920-5063
Publication type: Academic Journal
DOI: 10.1080/09205063.2024.2333068

Evaluating a promising methylcellulose hydrogel for enhanced diabetic foot ulcer therapy through comprehensive preclinical studies.

Patel, Priya; Dongre, Sanika; Patel, Alkesh; Patel, Gayatri