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- Title
Astilbe thunbergii reduces postprandial hyperglycemia in a type 2 diabetes rat model via pancreatic alpha-amylase inhibition by highly condensed procyanidins.
- Authors
Kato, Eisuke; Kushibiki, Natsuka; Inagaki, Yosuke; Kurokawa, Mihoko; Kawabata, Jun
- Abstract
Type 2 diabetes mellitus (T2DM) is a common global health problem. Prevention of this disease is an important task, and functional food supplements are considered an effective method. We found potent pancreatic α-amylase inhibition inAstilbe thunbergiiroot extract (AT) and confirmed that AT treatment in a T2DM rat model reduces post-starch administration blood glucose levels. Activity-guided isolation revealed procyanidin (AT-P) as the α-amylase inhibitory component with IC50 = 1.7 μg/mL against porcine pancreatic α-amylase. Structure analysis of AT-P revealed it is a B-type procyanidin comprised of four types of flavan-3-ols, some with a galloyl group, and catechin attached as the terminal unit. The abundant AT-P content and its comparable α-amylase inhibition to acarbose, the anti-diabetic medicine, suggest that AT is a promising food supplement for diabetes prevention. Astilbe thunbergiiextract showed anti-diabetic effect against type-2 diabetes mellitus rat model. Procyanidin was isolated as an active compound with potent α-amylase inhibition.
- Subjects
PROCYANIDINS; ASTILBE; SAXIFRAGACEAE
- Publication
Bioscience, Biotechnology & Biochemistry, 2017, Vol 81, Issue 9, p1699
- ISSN
0916-8451
- Publication type
Academic Journal
- DOI
10.1080/09168451.2017.1353403