The Protective Role of Phenolic Compounds Against Doxorubicin-induced Cardiotoxicity: A Comprehensive Review.

Razavi-Azarkhiavi, Kamal; Iranshahy, Milad; Sahebkar, Amirhossein; Shirani, Kobra; Karimi, Gholamreza

Although doxorubicin (DOX) is among the most widely used anticancer agents, its clinical application is hampered owing to its cardiotoxicity. Adjuvant therapy with an antioxidant has been suggested as a promising strategy to reduce DOX-induced adverse effects. In this context, many phenolic compounds have been reported to protect against DOX-induced cardiotoxicity. The cardioprotective effects of phenolic compounds are exerted via multiple mechanisms including inhibition of reactive oxygen species generation, apoptosis, NF-κB, p53, mitochondrial dysfunction, and DNA damage. In this review, we present a summary of the in vitro, in vivo, and clinical findings on the protective mechanisms of phenolic compounds against DOX-induced cardiotoxicity.

FLAVONOIDS; PHENOLS; THERAPEUTIC use of olive oil; ANTINEOPLASTIC agents; ANTIOXIDANTS; CARDIOTOXICITY; DOXORUBICIN; MITOCHONDRIA; NUTRITION; OXIDATIVE stress; RESVERATROL; CURCUMIN; THERAPEUTICS

Nutrition & Cancer, 2016, Vol 68, Issue 6, p892

0163-5581

Academic Journal

10.1080/01635581.2016.1187280