Electrophysiological Safety of Novel Fluoroquinolone Antibiotic Agents Gemifloxacin and Balofloxacin.

Seop Kim, Dong; Kim, Ki-Suk; Hwan Choi, Ki; Na, HanKwang; Kim, Joo-il; Shin, Won-Ho; Kim, Eun-Joo

Some fluoroquinolones have been reported to induce QT interval prolongation associated with the onset of torsades de pointes (TdP), resulting in a life-threatening ventricular arrhythmia. We investigated the cardiac electrophysiological effects of two new fluoroquinolones, gemifloxacin and balofloxacin, by using conventional microelectrode recording techniques in isolated rabbit Purkinje fiber and whole-cell patch-clamp techniques in human ether-á-go-go related gene (hERG)-transient transfected CHO cells. Gemifloxacin had no significant effects on the resting membrane potential, total amplitude, action potential, and V max of phase 0 depolarization at concentrations up to 30 μM, but gemifloxacin at 100 μM significantly decreased total amplitude (p

PATHOGENIC microorganisms; QUINOLONE antibacterial agents; SYNTHETIC drugs; PHARMACODYNAMICS; TOXICITY testing; ARRHYTHMIA; HEART diseases; SIDE effects of antibiotics; TOXICOLOGICAL chemistry

Drug & Chemical Toxicology, 2006, Vol 29, Issue 3, p303

0148-0545

Academic Journal

10.1080/01480540600652996