Title: Synthesis, crystal structures, and cytotoxicity of 2-benzoylpyridine N(4)-cyclohexylthiosemicarbazone and its zinc(II) and diorganotin(IV) complexes.
Authors: Yang, Min; Zhang, Ya-Hong; Li, Ming-Xue; Lu, Yan-Li; Zhang, Nan
Abstract: [Zn(L)2] (1) and [(Ph)2Sn(L)(CH3COO)] (2), where HL = 2-benzoylpyridine N(4)-cyclohexylthiosemicarbazone, have been synthesized and characterized. The complexes show different coordination depending on their coordinating preferences. Biological studies carried outin vitroagainst human leukemia K562 cells show that the diorgantin(IV) complex,2, has significant cytotoxicity with IC50 = 3.3 ± 0.5 ?M.
Subjects: CRYSTAL structure; CELL-mediated cytotoxicity; PYRIDINE synthesis; THIOSEMICARBAZONES; ZINC compounds; ORGANOTIN compounds; METAL complexes
Publication: Journal of Coordination Chemistry, 2013, Vol 66, Issue 19, p3327
ISSN: 0095-8972
Publication type: Academic Journal
DOI: 10.1080/00958972.2013.834333

Synthesis, crystal structures, and cytotoxicity of 2-benzoylpyridine N(4)-cyclohexylthiosemicarbazone and its zinc(II) and diorganotin(IV) complexes.

Yang, Min; Zhang, Ya-Hong; Li, Ming-Xue; Lu, Yan-Li; Zhang, Nan