Supramolecular organotin(IV) dithiocarboxylates as potential antimicrobial agents.

Zia-ur-Rehman; Muhammad, Niaz; Shah, Afzal; Ali, Saqib; Butler, IanS.; Meetsma, Auke

A series of tri-, chlorodi-, and diorganotin(IV) derivatives of 4-(2-methoxyphenyl)piperazine-1-carbodithioate (L) {R = n-C4H9 (1), C6H11 (2), CH3 (3) and C6H5 (4)}, (n-C4H9)2SnClL (5) and R2SnL2 {R = n-C4H9 (6), C2H5 (7), CH3 (8)} have been synthesized by refluxing organotin(IV) chlorides with the ligand-salt in the appropriate molar ratio. Elemental analysis, Raman, IR, multinuclear NMR (1H, 13C and 119Sn), mass spectroscopic, and single-crystal X-ray crystallographic studies were undertaken to elucidate the structures of the new compounds both in solution and in the solid state. The X-ray diffraction work reveals supramolecular structures for 4 and 6, with distorted trigonal-bipyramidal and distorted octahedral geometries around Sn, respectively. The ligand and several of the new compounds are good antimicrobial agents.

SUPRAMOLECULAR chemistry; ORGANOTIN compounds; THIOCARBOXYLATES; ANTI-infective agents; DRUG synergism; MOLECULAR spectroscopy; X-ray crystallography; LIGANDS (Chemistry); CHLORIDES

Journal of Coordination Chemistry, 2012, Vol 65, Issue 18, p3238

0095-8972

Academic Journal

10.1080/00958972.2012.707316