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Title: Synthesis of a ruthenium(II) polypyridine complex with 1,10-phenanthrolineselenazole as ligand and investigation of its G-quadruplex DNA-binding properties.
Authors: Yuan, Fang; Chen, Xiaojia; Zhou, Yanhui; Yang, Fang; Zhang, Qianling; Liu, Jie
Abstract: A new Ru(II) complex, [Ru(bpy)2L](ClO4)2 (bpy = 2,2′-bipyridine, L = 1,10-phenanthrolineselenazole), has been synthesized and structurally characterized by elemental analysis, ESI-MS, and 1H NMR. The interaction of human telomeric oligomer 5′-AG3(T2AG3)3-3′ with the Ru(II) complex was explored by competition FRET experiment, ﬂuorescence titration, circular dichroism spectroscopy, thermal denaturation, polymerase chain reaction stop assay, and TRAP assay. The Ru(II) complex can selectively bind to G-quadruplex DNA. The results indicated that the complex not only induces a remarkable conformational change of human telomeric DNA, but also has the ability to stabilize the G-quadruplex.
Subjects: TRANSITION metal complexes; ORGANORUTHENIUM compounds; POLYPYRIDINES; COMPLEX compounds synthesis; DNA-ligand interactions; OLIGOMERS; CHEMICAL structure; POLYMERASE chain reaction
Publication: Journal of Coordination Chemistry, 2012, Vol 65, Issue 7, p1246
ISSN: 0095-8972
Publication type: Academic Journal
DOI: 10.1080/00958972.2012.670228

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Synthesis of a ruthenium(II) polypyridine complex with 1,10-phenanthrolineselenazole as ligand and investigation of its G-quadruplex DNA-binding properties.