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- Title
New supramolecular ferrocenyl amides: synthesis, characterization, and preliminary DNA-binding studies.
- Authors
Javed, Fatima; Altaf, AtafAli; Badshah, Amin; Tahir, MuhammadNawaz; Siddiq, Muhammad; Zia-Ur-Rehman; Shah, Afzal; Ullah, Shafiq; Lal, Bhajan
- Abstract
Three ferrocenyl amides have been synthesized and characterized by analytical techniques. Based on single-crystal X-ray analysis, a supramolecular structure was attributed to 1 owing to the presence of intermolecular non-covalent interactions. UV-Visible spectroscopy, viscometry, and dynamic laser light scattering was used to assess the mode of interaction and binding of these complexes with DNA, which varied in the sequence 1 > 2 > 3. The binding is presumably due to the ability of these complexes to form secondary non-covalent interactions with DNA bases. Complex-DNA adduct formation depends on the nature of R of the amide.
- Subjects
COMPLEX compounds synthesis; DNA-ligand interactions; AMIDES; SUPRAMOLECULAR chemistry; LIGHT scattering; ULTRAVIOLET spectroscopy; MOLECULAR structure; X-ray crystallography
- Publication
Journal of Coordination Chemistry, 2012, Vol 65, Issue 6, p969
- ISSN
0095-8972
- Publication type
Academic Journal
- DOI
10.1080/00958972.2012.664769