Title: New supramolecular ferrocenyl amides: synthesis, characterization, and preliminary DNA-binding studies.
Authors: Javed, Fatima; Altaf, AtafAli; Badshah, Amin; Tahir, MuhammadNawaz; Siddiq, Muhammad; Zia-Ur-Rehman; Shah, Afzal; Ullah, Shafiq; Lal, Bhajan
Abstract: Three ferrocenyl amides have been synthesized and characterized by analytical techniques. Based on single-crystal X-ray analysis, a supramolecular structure was attributed to 1 owing to the presence of intermolecular non-covalent interactions. UV-Visible spectroscopy, viscometry, and dynamic laser light scattering was used to assess the mode of interaction and binding of these complexes with DNA, which varied in the sequence 1 > 2 > 3. The binding is presumably due to the ability of these complexes to form secondary non-covalent interactions with DNA bases. Complex-DNA adduct formation depends on the nature of R of the amide.
Subjects: COMPLEX compounds synthesis; DNA-ligand interactions; AMIDES; SUPRAMOLECULAR chemistry; LIGHT scattering; ULTRAVIOLET spectroscopy; MOLECULAR structure; X-ray crystallography
Publication: Journal of Coordination Chemistry, 2012, Vol 65, Issue 6, p969
ISSN: 0095-8972
Publication type: Academic Journal
DOI: 10.1080/00958972.2012.664769

New supramolecular ferrocenyl amides: synthesis, characterization, and preliminary DNA-binding studies.

Javed, Fatima; Altaf, AtafAli; Badshah, Amin; Tahir, MuhammadNawaz; Siddiq, Muhammad; Zia-Ur-Rehman; Shah, Afzal; Ullah, Shafiq; Lal, Bhajan