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- Title
Synthesis, spectral analysis, and molecular modeling of bioactive Sn(II)-complexes with oxadiazole Schiff bases.
- Authors
Khedr, Abdalla M.; Jadon, Sudha; Kumar, Vipin
- Abstract
Sn(II)-complexes of seven 2-amino-5-substituted-aryl-1,3,4-oxadiazole Schiff bases have been synthesized and characterized by various physico-chemical studies. Their structures have been confirmed by elemental analyses, infrared, 1H NMR, UV-Vis, and mass spectral studies as well as thermal decomposition. Conductance measurements in methanol show these complexes to be non-electrolytes, and the molecular weight determinations support the proposed molecular formulae. The molecular structures of the complexes have been optimized by CS Chem 3-D Ultra Molecular Modeling and Analysis Program showing tetrahedral geometry. The bio-efficacy of the complexes has been examined against the growth of bacteria (Escherichia coli and Staphylococcus aureus) and fungi (Aspergillus flavus and Candida albicans) in vitro to evaluate their anti-microbial potential.
- Subjects
MOLECULAR models; BIOACTIVE compounds; SCHIFF bases; METAL complexes; SPECTRUM analysis; BACTERIAL growth; OXAZOLES; COMPLEX compounds synthesis
- Publication
Journal of Coordination Chemistry, 2011, Vol 64, Issue 8, p1351
- ISSN
0095-8972
- Publication type
Academic Journal
- DOI
10.1080/00958972.2011.569541