The possibility of using atmospheric pressure dielectric barrier discharge plasma treatment for textile surface activation to facilitate deposition of nano TiO2/SiO2 onto cotton fabric is investigated. It is aimed to develop a multifunctional cotton textile using plasma and nanotechnology. The treated fabric is evaluated through measuring the ultraviolet protection factor, antimicrobial activity, and flame retardancy as functional finishes. Surface morphology (Scanning electron microscopy, SEM), thermogravimetric analysis, and mechanical properties were also studied. SEM shows deposition of nanoparticles onto the fabric. He–O2 plasma pretreatment improves the flame retardancy, antibacterial activity, and thermal stability of the samples were compared with the untreated samples.