Analysis of influencing factors of exercise systolic blood pressure response in nonalcoholic fatty liver disease aged 40–60 years.

Hao, Xiaoyan; Zhang, Huihui; He, Honghai; Tao, Liyuan; Tian, Lei; Zhao, Wei; Wang, Peng

Objectives: This study investigated the influencing factors of exercise systolic blood pressure response (ESBPR) by cardiopulmonary exercise test (CPX) in nonalcoholic fatty liver disease (NAFLD) in people aged 40–60 years. Methods: A total of 603 adults were enrolled in this study. The inclusion criteria of this cross-sectional study were adults who underwent health checks and CPX. Results: There were significant differences in body mass Index (BMI) (26.80 ± 2.64 VS 23.31 ± 2.41, p < 0.001) kg/m2, fasting blood glucose (FPG) (5.56 ± 0.94 VS 5.13 ± 0.55, p < 0.001) mmol/L, alanine aminotransferase (ALT), aspartate transaminase (AST), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C) (1.13 ± 0.22 VS 1.43 ± 0.33, p < 0.001) mmol/L, low-density lipoprotein-cholesterol (LDL-C) (3.21 ± 0.79 VS 2.99 ± 0.68, p = 0.001) mmol/L, resting systolic blood pressure (SBP) (123.53 ± 14.73 VS 118.79 ± 14.79, p < 0.001) mmHg, resting diastolic blood pressure (DBP) (80.29 ± 9.62 VS 75.27 ± 10.41, p < 0.001) mmHg, peak SBP (184.01 ± 23.50 VS 172.81 ± 24.95, p < 0.001) mmHg, peak DBP (87.47 ± 10.50 VS 84.01 ± 11.46, p = 0.001) mmHg, oxygen pulse (VO2/HR) (0.88 ± 0.15 VS 0.92 ± 0.16, p = 0.004) ml/beat, exercise maximum heart rate, carbon dioxide Ventilation equivalent (VE/VCO2) (25.84 ± 4.43 VS 25.12 ± 3.58, p = 0.038), peak oxygen uptake (VO2 peak) (1.78 ± 0.45 VS 1.56 ± 0.46, p < 0.001) mL/min between the NAFLD and control groups. VE/VCO2 (OR = 0.822, p = 0.036) and oxygen uptake/work rate (VO2/WR) (OR = 0.517, p = 0.021) mL/min/watt were associated with a lower risk of ESBPR in NAFLD subjects. Resting SBP was associated with a higher risk of ESBPR in NAFLD patients (OR = 1.059, p = 0.003) and overweight NAFLD subjects (OR = 1.075, p = 0.002). ESBPR (OR = 1.268, p = 0.045), skeletal-muscle mass (OR = 1.305, p < 0.001), and SMI (OR = 1.315, p < 0.001) were linked to an elevated risk of NAFLD in individuals. Conclusion: Our findings indicate that ESBPR is associated with an increased risk of NAFLD in individuals aged 40–60 years. Furthermore, in NAFLD subjects, VE/VCO2 and VO2/WR were found to be correlated with a decreased risk of ESBPR, whereas resting SBP was linked to an elevated risk of ESBPR. This will provide a research basis for the NAFLD subjects who have ESBPR at risk of adverse events during exercise.

NON-alcoholic fatty liver disease; DIASTOLIC blood pressure; SYSTOLIC blood pressure; EXERCISE tests; ASPARTATE aminotransferase

Postgraduate Medicine, 2025, Vol 137, Issue 1, p79

0032-5481

Academic Journal

10.1080/00325481.2024.2436344