Title: Equilibrium solubility and mathematical modelling of glibenclamide in cosolvent mixtures of glycols and alcohols.
Authors: Nouri, Leila; Rahimpour, Elaheh; Jouyban, Abolghasem
Abstract: Glibenclamide (GBN) is a commonly used oral medication for treating type-II diabetes that acts by reducing high blood sugar levels. The effectiveness of GBN depends on the quality of the product. The quality is influenced by the solubility properties of a drug. This study aimed to measure the solubility of GBN in various solvent mixtures including some glycols and alcohols. The solubility was determined using a shake-flask method at 298.2 K under atmospheric pressure. The results showed that GBN had the highest solubility in ethylene glycol monomethyl ether and alcohol mixtures compared to the other tested glycols.
Subjects: METHOXYETHANOL; HYPERGLYCEMIA; BINARY mixtures; DRUG solubility; ATMOSPHERIC pressure
Publication: Physics & Chemistry of Liquids, 2025, Vol 63, Issue 1, p108
ISSN: 0031-9104
Publication type: Academic Journal
DOI: 10.1080/00319104.2024.2372559

Equilibrium solubility and mathematical modelling of glibenclamide in cosolvent mixtures of glycols and alcohols.

Nouri, Leila; Rahimpour, Elaheh; Jouyban, Abolghasem