Effect of a probiotic (Lactobacillus sp.), yeast (Saccharomyces cerevisiae) and mycotoxin detoxifier alone or in combination on performance, immune response and serum biochemical parameters in broilers fed deoxynivalenol-contaminated diets.

Azizi, Tayebe; Daneshyar, Mohsen; Allymehr, Manoochehr; Tukmechi, Amir; Behroozyar, Hamed Khalilvandi; Jalali, Ali Shalizar

Context: Deoxynivalenol (DON) contamination of feedstuffs causes detrimental effects on animals and poultry. Dietary inclusion of microbial feed additives, such as probiotics and/or yeast, seems to be a useful approach for DON detoxification and reducing the toxin absorption from the gut. Aims: This study was conducted to evaluate the synergetic effects of a probiotic (Lactobacillus spp.), yeast (Saccharomyces cerevisiae) and mycotoxin detoxifier on performance, serum chemical parameters and immune status of broiler chickens fed a DON-contaminated diet. Methods: A total of 200 1-day-old female broilers (Hubbard®) were allocated to five dietary treatments with four replicates each in a completely randomised design. Experimental diets consisted of: (1) control diet (basal diet), (2) DON diet (basal diet contaminated with 10 mg/kg DON), (3) DON diet supplemented with 0.25% mycotoxin detoxifier (Mycofix® Plus), (4) DON diet supplemented with a combination of 0.4 g/kg probiotic and 1.5 g/kg yeast, and (5) DON diet supplemented with a combination of a probiotic, yeast and mycotoxin detoxifier. Key results: The results showed that the DON diet significantly increased the feed conversion ratio compared with mycotoxin detoxifier and control diets. Administration of 0.4 g/kg probiotic along with 1.5 g/kg yeast to a DON-contaminated diet caused a significant enhancement of dressing percentage, leg relative weight and aspartate aminotransferase enzyme activity. The DON-contaminated diet reduced total protein, albumin, triglyceride and cholesterol concentrations, but consumption of a probiotic, yeast and mycotoxin detoxifier improved the levels of these parameters. The DON-treated birds showed a reduction in haematocrit, haemoglobin, red blood cells and blood lymphocyte percentage in comparison with control levels. The inclusion of a combination of a probiotic and yeast along with mycotoxin detoxifier diminished the increased heterophil: lymphocyte ratio by DON administration. The antibody titre against Newcastle disease virus vaccine increased by inclusion of a probiotic, yeast and Mycofix. Conclusions: In summary, a combination of a probiotic and yeast along with mycotoxin detoxifier can improve the enzyme activity, immunity and haematological attributes, which are useful for DON-contaminated diet detoxification. Implications: Dietary supplementation with a probiotic, yeast and mycotoxin detoxifier could be used as an alternative to detoxification DON in broiler chickens. Deoxynivalenol is a major mycotoxin that can be detected in cereal grains. It can cause a growth reduction in broiler chickens and endanger human health. Consumption of deoxynivalenol can reduce the production efficiency of animals and cause severe economic losses. Consequently, some feed additives are used as a detoxifier, which ameliorate the detrimental effects of deoxynivalenol on growth performance and the immune system.

PROBIOTICS; MYCOTOXINS; IMMUNE serums; FUSARIUM toxins; SACCHAROMYCES cerevisiae; NEWCASTLE disease vaccines; ERYTHROCYTES; YEAST

Animal Production Science, 2021, Vol 61, Issue 15, p1553

1836-0939

Academic Journal

10.1071/AN19728