Works matching Howard Hughes

Results: 5000
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    New Howard Hughes Investigators Named.

    Published in:
    JAMA: Journal of the American Medical Association, 2005, v. 293, n. 17, p. 2082, doi. 10.1001/jama.293.17.2082
    By:
    • Hampton, Tracy
    Publication type:
    Article
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    The Silicon Marvel.

    Published in:
    Bio-IT World, 2010, v. 9, n. 4, p. 48
    By:
    • BARRETT, RANDY
    Publication type:
    Article
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    Howard Hughes: Aviator.

    Published in:
    Air & Space Power Journal, 2019, v. 33, n. 3, p. 96
    By:
    • Kester, Marissa
    Publication type:
    Article
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    Short Synthesis of Skeletally and Stereochemically Diverse Small Molecules by Coupling Petasis Condensation Reactions to Cyclization ReactionsThe NIGMS-sponsored Center of Excellence in Chemical Methodology and Library Design (Broad Institute CMLD) enabled this research. We thank Nilesh Kumar and Drs. Paul Clemons, Ryan Looper, Xiang Wang, and Damian Young for helpful discussions. G.M. is a visiting PhD student from the Dipartimento Farmacochimico, University of Bari (Italy). S.L.S. is an Investigator with the Howard Hughes Medical Institute.

    Published in:
    Angewandte Chemie, 2006, v. 118, n. 22, p. 3717, doi. 10.1002/ange.200600497
    By:
    • Naoya Kumagai;
    • Giovanni Muncipinto;
    • Stuart L. Schreiber
    Publication type:
    Article
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    Convergent Diversity-Oriented Synthesis of Small-Molecule HybridsWe thank the NIGMS for support of this research. C.C. is a research associate and S.L.S is an investigator with the Howard Hughes Medical Institute at the Department of Chemistry and Chemical Biology, Harvard University. C.S.N. acknowledges an NSF predoctoral fellowship.

    Published in:
    Angewandte Chemie, 2005, v. 117, n. 15, p. 2289, doi. 10.1002/ange.200462798
    By:
    • Chuo Chen;
    • Xiaodong Li;
    • Christopher S. Neumann;
    • Michael M.-C. Lo;
    • Stuart L. Schreiber
    Publication type:
    Article
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    A Packing-Density Metric for Exploring the Interior of Folded RNA MoleculesWe thank Rui Sousa for the gift of the Y639F T7 RNA polymerase plasmid, Kara Juneau and Tom Cech for the ?C209 P4-P6 plasmid, Cecilia Cortez and Shirshendu Deb for assistance with nucleoside synthesis, Joe Olvera for technical assistance, and Cheryl Small for assistance with manuscript preparation. We also thank members of the Piccirilli group and the reviewers for their comments on the manuscript. N.S.L. is a Research Specialist, and J.A.P. is an Associate Investigator of the Howard Hughes Medical Institute.

    Published in:
    Angewandte Chemie, 2004, v. 116, n. 23, p. 3095, doi. 10.1002/ange.200353575
    By:
    • Jason P. Schwans;
    • Nan-Sheng Li;
    • Joseph A. Piccirilli
    Publication type:
    Article
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    Synthetic Strategy toward Skeletal Diversity via Solid-Supported, Otherwise Unstable Reactive Intermediates ( We are especially grateful to John Tallarico and Max Narovlyansky at ICCB for the donation of synthesis resin. S.J.T. was supported by a postdoctoral fellowship (DRG-1735-02) of the Damon Runyon Cancer Research Foundation. A.M.T. was supported by a training grant managed by the Molecular, Cellular, and Chemical Biology Program. S.L.S. is an investigator at the Howard Hughes Medical Institute in the Department of Chemistry and Chemical Biology. We thank the National Institute for General Medical Sciences for their support of this research, the National Cancer Institute (NCI), Merck KGaA, Merck & Co., and the Keck Foundation for their support of ICCB, and the NCI for their support of the Initiative for Chemical Genetics. )

    Published in:
    Angewandte Chemie, 2004, v. 116, n. 13, p. 1713, doi. 10.1002/ange.200353466
    By:
    • Steven J. Taylor;
    • Alexander M. Taylor;
    • Stuart L. Schreiber
    Publication type:
    Article
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    An Integrated Approach to a Portable and Low-Cost Immunoassay for Resource-Poor Settings (This research was supported by DARPA/NSF (ECS-0004030) and NIH (GM 65364), and used the MRSEC shared facilities supported by the NSF under Award No. DMR-9809363. V.L. was a recipient of a postdoctoral fellowship from the Swiss National Science Foundation. A.S. was a recipient of a Howard Hughes Medical Institute Predoctoral Fellowship. We thank Tyler Aldredge of the Center for Genomics Research for technical assistance.)

    Published in:
    Angewandte Chemie, 2004, v. 116, n. 4, p. 504, doi. 10.1002/ange.200353016
    By:
    • Samuel K. Sia;
    • Vincent Linder;
    • Babak Amir Parviz;
    • Adam Siegel;
    • George M. Whitesides
    Publication type:
    Article
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    A Concise and Flexible Total Synthesis of (-)-Diazonamide A ( Funding provided by the NIH (RO1-GM60591), the Howard Hughes Medical Institute, the Robert A. Welch Foundation, and unrestricted research awards from AstraZeneca, Eli Lilly, and Pfizer are gratefully acknowledged. P.H. is a fellow of the Alfred P. Sloan Foundation. A.B. thanks the medicinal chemistry section of the ACS for a pre-doctoral fellowship (sponsor: Aventis Pharmaceuticals). We are indebted to Dr. Nigam Rath (University of Missouri at St. Louis) for his crystallographic analysis of aminal 15. )

    Published in:
    Angewandte Chemie, 2003, v. 115, n. 40, p. 5111, doi. 10.1002/ange.200352577
    By:
    • Anthony W. G. Burgett;
    • Qingyi Li;
    • Qi Wei;
    • Patrick G. Harran
    Publication type:
    Article
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    Expanding the Functional Group Compatibility of Small-Molecule Microarrays: Discovery of Novel Calmodulin Ligands () We are especially grateful to John Tallarico and Max Narovlyansky of the Harvard Institute of Chemistry and Cell Biology (ICCB) for donation of 2 b and synthesis resin, and to Jason Gatlin and Jennifer Raggio of the ICCB for their assistance with decoding. A.N.K. was supported by an Eli Lilly Predoctoral Fellowship. S.B.P. and D.B.-S. are Research Associates and S.L.S. is an Investigator at the Howard Hughes Medical Institute in the Department of Chemistry and Chemical Biology. We thank the National Institute for General Medical Sciences for support of this research, the National Cancer Institute (NCI), Merck KGaA, Merck & Co., and the Keck Foundation for support of the ICCB, and the NCI for support of the Initiative for Chemical Genetics (formerly known as the Molecular Target Laboratory).

    Published in:
    Angewandte Chemie, 2003, v. 115, n. 21, p. 2478, doi. 10.1002/ange.200351043
    By:
    • David Barnes-Seeman;
    • Seung Bum Park;
    • Angela N. Koehler;
    • Stuart L. Schreiber
    Publication type:
    Article
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    Total Synthesis and Absolute Configuration of the Novel Microtubule-Stabilizing Agent Peloruside A ( Financial support provided by the Advanced Research Program of the Texas Higher Education Coordinating Board, the Robert A. Welch Foundation, and the Howard Hughes Medical Institute (junior faculty support). J.K.D.B. is a fellow of the Alfred P. Sloan Foundation. )

    Published in:
    Angewandte Chemie, 2003, v. 115, n. 14, p. 1686, doi. 10.1002/ange.200351145
    By:
    • Xibin Liao;
    • Yusheng Wu;
    • Jef K. De Brabander
    Publication type:
    Article
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    Short Synthesis of Skeletally and Stereochemically Diverse Small Molecules by Coupling Petasis Condensation Reactions to Cyclization ReactionsThe NIGMS-sponsored Center of Excellence in Chemical Methodology and Library Design (Broad Institute CMLD) enabled this research. We thank Nilesh Kumar and Drs. Paul Clemons, Ryan Looper, Xiang Wang, and Damian Young for helpful discussions. G.M. is a visiting PhD student from the Dipartimento Farmacochimico, University of Bari (Italy). S.L.S. is an Investigator with the Howard Hughes Medical Institute.

    Published in:
    Angewandte Chemie International Edition, 2006, v. 45, n. 22, p. 3635, doi. 10.1002/anie.200600497
    By:
    • Naoya Kumagai;
    • Giovanni Muncipinto;
    • Stuart L. Schreiber
    Publication type:
    Article
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    Convergent Diversity-Oriented Synthesis of Small-Molecule HybridsWe thank the NIGMS for support of this research. C.C. is a research associate and S.L.S is an investigator with the Howard Hughes Medical Institute at the Department of Chemistry and Chemical Biology, Harvard University. C.S.N. acknowledges an NSF predoctoral fellowship.

    Published in:
    Angewandte Chemie International Edition, 2005, v. 44, n. 15, p. 2249, doi. 10.1002/anie.200462798
    By:
    • Chuo Chen;
    • Xiaodong Li;
    • Christopher S. Neumann;
    • Michael M.-C. Lo;
    • Stuart L. Schreiber
    Publication type:
    Article
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    Synthetic Strategy toward Skeletal Diversity via Solid-Supported, Otherwise Unstable Reactive Intermediates ( We are especially grateful to John Tallarico and Max Narovlyansky at ICCB for the donation of synthesis resin. S.J.T. was supported by a postdoctoral fellowship (DRG-1735-02) of the Damon Runyon Cancer Research Foundation. A.M.T. was supported by a training grant managed by the Molecular, Cellular, and Chemical Biology Program. S.L.S. is an investigator at the Howard Hughes Medical Institute in the Department of Chemistry and Chemical Biology. We thank the National Institute for General Medical Sciences for their support of this research, the National Cancer Institute (NCI), Merck KGaA, Merck & Co., and the Keck Foundation for their support of ICCB, and the NCI for their support of the Initiative for Chemical Genetics. )

    Published in:
    Angewandte Chemie International Edition, 2004, v. 43, n. 13, p. 1681, doi. 10.1002/anie.200353466
    By:
    • Steven J. Taylor;
    • Alexander M. Taylor;
    • Stuart L. Schreiber
    Publication type:
    Article
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    An Integrated Approach to a Portable and Low-Cost Immunoassay for Resource-Poor Settings (This research was supported by DARPA/NSF (ECS-0004030) and NIH (GM 65364), and used the MRSEC shared facilities supported by the NSF under Award No. DMR-9809363. V.L. was a recipient of a postdoctoral fellowship from the Swiss National Science Foundation. A.S. was a recipient of a Howard Hughes Medical Institute Predoctoral Fellowship. We thank Tyler Aldredge of the Center for Genomics Research for technical assistance.)

    Published in:
    Angewandte Chemie International Edition, 2004, v. 43, n. 4, p. 498, doi. 10.1002/anie.200353016
    By:
    • Samuel K. Sia;
    • Vincent Linder;
    • Babak Amir Parviz;
    • Adam Siegel;
    • George M. Whitesides
    Publication type:
    Article
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    A Concise and Flexible Total Synthesis of (-)-Diazonamide A ( Funding provided by the NIH (RO1-GM60591), the Howard Hughes Medical Institute, the Robert A. Welch Foundation, and unrestricted research awards from AstraZeneca, Eli Lilly, and Pfizer are gratefully acknowledged. P.H. is a fellow of the Alfred P. Sloan Foundation. A.B. thanks the medicinal chemistry section of the ACS for a pre-doctoral fellowship (sponsor: Aventis Pharmaceuticals). We are indebted to Dr. Nigam Rath (University of Missouri at St. Louis) for his crystallographic analysis of aminal 15. )

    Published in:
    Angewandte Chemie International Edition, 2003, v. 42, n. 40, p. 4961, doi. 10.1002/anie.200352577
    By:
    • Anthony W. G. Burgett;
    • Qingyi Li;
    • Qi Wei;
    • Patrick G. Harran
    Publication type:
    Article
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    Expanding the Functional Group Compatibility of Small-Molecule Microarrays: Discovery of Novel Calmodulin Ligands ( We are especially grateful to John Tallarico and Max Narovlyansky of the Harvard Institute of Chemistry and Cell Biology (ICCB) for donation of 2 b and synthesis resin, and to Jason Gatlin and Jennifer Raggio of the ICCB for their assistance with decoding. A.N.K. was supported by an Eli Lilly Predoctoral Fellowship. S.B.P. and D.B.-S. are Research Associates and S.L.S. is an Investigator at the Howard Hughes Medical Institute in the Department of Chemistry and Chemical Biology. We thank the National Institute for General Medical Sciences for support of this research, the National Cancer Institute (NCI), Merck KGaA, Merck & Co., and the Keck Foundation for support of the ICCB, and the NCI for support of the Initiative for Chemical Genetics (formerly known as the Molecular Target Laborato)

    Published in:
    Angewandte Chemie International Edition, 2003, v. 42, n. 21, p. 2376, doi. 10.1002/anie.200351043
    By:
    • David Barnes-Seeman;
    • Seung Bum Park;
    • Angela N. Koehler;
    • Stuart L. Schreiber
    Publication type:
    Article
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    Total Synthesis and Absolute Configuration of the Novel Microtubule-Stabilizing Agent Peloruside A ( Financial support provided by the Advanced Research Program of the Texas Higher Education Coordinating Board, the Robert A. Welch Foundation, and the Howard Hughes Medical Institute (junior faculty support). J.K.D.B. is a fellow of the Alfred P. Sloan Foundation. )

    Published in:
    Angewandte Chemie International Edition, 2003, v. 42, n. 14, p. 1648, doi. 10.1002/anie.200351145
    By:
    • Xibin Liao;
    • Yusheng Wu;
    • Jef K. De Brabander
    Publication type:
    Article
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