Lymphoma is known to cause a wide spectrum of neurological disorders, including local lymphomatous infiltration and paraneoplastic syndrome. Intrathecal chemotherapy with MTX and Ara-C are routinely use for CNS prophylaxis alongside systemic chemotherapy in the treatment of leukemia and lymphoma. Chemotherapy-induced neurological syndromes encompass encephalopathy, seizures, arachnoiditis, cranial neuropathies, caudal equina syndrome, and peripheral neuropathy.