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A phase I trial of lomeguatrib and irinotecan in metastatic colorectal cancer.
Published in:
Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 5, p. 829, doi. 10.1007/s00280-009-1225-0
By:
- Sabharwal, A.;
- Corrie, P. G.;
- Midgley, R. S.;
- Palmer, C.;
- Brady, J.;
- Mortimer, P.;
- Watson, A. J.;
- Margison, G. P.;
- Middleton, M. R.
Publication type:
Article
Fern spore extracts can damage DNA.
Published in:
British Journal of Cancer, 2000, v. 83, n. 1, p. 69
By:
- Simán, S E;
- Povey, A C;
- Ward, T H;
- Margison, G P;
- Sheffield, E
Publication type:
Article
Dietary variables associated with DNA N7-methylguanine levels and O6-alkylguanine DNA-alkyltransferase activity in human colorectal mucosa.
Published in:
Carcinogenesis, 2009, v. 30, n. 4, p. 615, doi. 10.1093/carcin/bgp020
By:
- H. A. Billson;
- K. L. Harrison;
- N. P. Lees;
- C. N. Hall;
- G. P. Margison;
- A. C. Povey
Publication type:
Article
Bacterial and mammalian DNA alkyltransferases sensitize Escherichia coli to the lethal and mutagenic effects of dibromoalkanes.
Published in:
Carcinogenesis, 1997, v. 18, n. 10, p. 1883, doi. 10.1093/carcin/18.10.1883
By:
- Abril, N;
- Luque-Romero, F L;
- Prieto-Alamo, M J;
- Rafferty, J A;
- Margison, G P;
- Pueyo, C
Publication type:
Article
Low O6-alkylguanine DNA-alkyltransferase activity in normal colorectal tissue is associated with colorectal tumours containing a GC-->AT transition in the K-ras oncogene.
Published in:
Carcinogenesis, 1997, v. 18, n. 7, p. 1299, doi. 10.1093/carcin/18.7.1299
By:
- Jackson, P E;
- Hall, C N;
- O'Connor, P J;
- Cooper, D P;
- Margison, G P;
- Povey, A C
Publication type:
Article
Exploring molecular mechanisms in chemically induced cancer: Complementation of mammalian DNA repair defects by a prokaryotic gene.
Published in:
BioEssays, 1987, v. 6, n. 4, p. 151, doi. 10.1002/bies.950060402
By:
- Margison, G. P.;
- Brennand, J.;
- Ockey, C. H.;
- O'Connor, P. J.
Publication type:
Article
A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours.
Published in:
2011
By:
- Khan, O. A.;
- Gore, M.;
- Lorigan, P.;
- Stone, J.;
- Greystoke, A.;
- Burke, W.;
- Carmichael, J.;
- Watson, A. J.;
- McGown, G.;
- Thorncroft, M.;
- Margison, G. P.;
- Califano, R.;
- Larkin, J.;
- Wellman, S.;
- Middleton, M. R.
Publication type:
journal article
A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer.
Published in:
2009
By:
- Khan, O A;
- Ranson, M;
- Michael, M;
- Olver, I;
- Levitt, N C;
- Mortimer, P;
- Watson, A J;
- Margison, G P;
- Midgley, R;
- Middleton, M R
Publication type:
Correction Notice
A phase I study of extended dosing with lomeguatrib with temozolomide in patients with advanced melanoma.
Published in:
2009
By:
- Kefford, R. F.;
- Thomas, N. P. B.;
- Corrie, P. G.;
- Palmer, C.;
- Abdi, E.;
- Kotasek, D.;
- Beith, J.;
- Ranson, M.;
- Mortimer, P.;
- Watson, A. J.;
- Margison, G. P.;
- Middleton, M. R.
Publication type:
journal article
A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer.
Published in:
2008
By:
- Khan, O. A.;
- Ranson, M.;
- Michael, M.;
- Olver, I.;
- Levitt, N. C.;
- Mortimer, P.;
- Watson, A. J.;
- Margison, G. P.;
- Midgley, R.;
- Middleton, M. R.
Publication type:
journal article
Phase II study of SPI-77 (sterically stabilised liposomal cisplatin) in advanced non-small-cell lung cancer.
Published in:
2006
By:
- White, S. C.;
- Lorigan, P.;
- Margison, G. P.;
- Margison, J. M.;
- Martin, F.;
- Thatcher, N.;
- Anderson, H.;
- Ranson, M.
Publication type:
journal article
O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts.
Published in:
2005
By:
- Clemons, M.;
- Kelly, J.;
- Watson, A. J.;
- Howell, A.;
- McElhinney, R. S.;
- McMurry, T. B. H.;
- Margison, G. P.
Publication type:
journal article
Dose finding and O6-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies.
Published in:
2005
By:
- Geoerger, B.;
- Vassal, G.;
- Doz, F.;
- O'Quigley, J.;
- Wartelle, M.;
- Watson, A. J.;
- Raquin, M.-A.;
- Frappaz, D.;
- Chastagner, P.;
- Gentet, J.-C.;
- Rubie, H.;
- Couanet, D.;
- Geoffray, A.;
- Djafari, L.;
- Margison, G. P.;
- Pein, F.
Publication type:
journal article
Differential radiosensitisation by ZD1839 (Iressa), a highly selective epidermal growth factor receptor tyrosine kinase inhibitor in two related bladder cancer cell lines.
Published in:
2005
By:
- Maddineni, S. B.;
- Sangar, V. K.;
- Hendry, J. H.;
- Margison, G. P.;
- Clarke, N. W.
Publication type:
journal article
Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum.
Published in:
2002
By:
- Lees, N P;
- Harrison, K L;
- Hill, E;
- Hall, C N;
- Margison, G P;
- Povey, A C
Publication type:
journal article
Heterogeneity of O6-alkylguanine DNA-alkyltransferase expression in human breast tumours.
Published in:
2002
By:
- Clemons, M J;
- Bibby, M C;
- El Teraifi, H;
- Forster, G;
- Kelly, J;
- Banerjee, S;
- Cadman, B;
- Ryder, W D J;
- Howell, A;
- Margison, G P
Publication type:
journal article
Immunohistochemical analysis of expression and allelotype of mismatch repair genes (hMLH1 and hMSH2) in bladder cancer.
Published in:
British Journal of Cancer, 2001, v. 84, n. 3, p. 321, doi. 10.1054/bjoc.2000.1595
By:
- Kassem, H Sh;
- Varley, J M;
- Hamam, S M;
- Margison, G P
Publication type:
Article
Expression of Ku70 correlates with survival in carcinoma of the cervix.
Published in:
2000
By:
- Wilson, C R;
- Davidson, S E;
- Margison, G P;
- Jackson, S P;
- Hendry, J H;
- West, C M L;
- West, C M
Publication type:
journal article
Effect of expression of the Escherichia coli nth gene in Saccharomyces cerevisiae on the toxicity of ionizing radiation and hydrogen peroxide.
Published in:
International Journal of Radiation Biology, 2003, v. 79, n. 9, p. 747
By:
- Škorvaga, M.;
- Černáková, L.;
- Chovanec, M.;
- Vlasáková, D.;
- Kleibl, K.;
- Hendry, J. H.;
- Margison, G. P.;
- Brozmanová, J.
Publication type:
Article
Relationships between the Cytotoxic Effects of Restriction Endonucleases and Radiation on Mammalian Cells.
Published in:
International Journal of Radiation Biology, 1995, v. 67, n. 3, p. 327, doi. 10.1080/09553009514550381
By:
- Price, R. C.;
- Margison, G. P.;
- Hendry, J. H.;
- West, C. M. L.
Publication type:
Article
Development of a novel rapid assay to assess the fidelity of DNA double-strand-break repair in human tumour cells.
Published in:
Nucleic Acids Research, 2002, v. 30, n. 2, p. e1, doi. 10.1093/nar/30.2.e1
By:
- Collis, S. J.;
- Sangar, V. K.;
- Tighe, A.;
- Roberts, S. A.;
- Clarke, N. W.;
- Hendry, J. H.;
- Margison, G. P.
Publication type:
Article
Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells.
Published in:
Nucleic Acids Research, 2001, v. 29, n. 7, p. 1534, doi. 10.1093/nar/29.7.1534
By:
- Collis, S. J.;
- Tighe, A.;
- Scott, S. D.;
- Roberts, S. A.;
- Hendry, J. H.;
- Margison, G. P.
Publication type:
Article
Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenografts.
Published in:
2000
By:
- Middleton, Mark R.;
- Kelly, Jane;
- Goodger, Sarah;
- Thatcher, Nicholas;
- Margison, Geoffrey P.;
- Middleton, M R;
- Kelly, J;
- Goodger, S;
- Thatcher, N;
- Margison, G P
Publication type:
journal article
PON1 increases cellular DNA damage by lactone substrates.
Published in:
Archives of Toxicology, 2019, v. 93, n. 7, p. 2035, doi. 10.1007/s00204-019-02475-w
By:
- Shangula, S.;
- Noori, M.;
- Ahmad, I.;
- Margison, G. P.;
- Liu, Y.;
- Siahmansur, T.;
- Soran, H.;
- Povey, A. C.
Publication type:
Article
Protection of committed murine haemopoietic progenitors against BCNU toxicity does not predict protection of primitive, multipotent spleen colony-forming cells - implications for chemoprotective gene therapy.
Published in:
1999
By:
- Chinnasamy, N;
- Rafferty, J A;
- Lashford, L S;
- Chinnasamy, D;
- Margison, G P;
- Thatcher, N;
- Dexter, T M;
- Fairbairn, L J;
- Rafferty, J;
- Lashford, L;
- Margison, G;
- Dexter, T;
- Fairbairn, L
Publication type:
journal article
Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus.
Published in:
Gene Therapy, 2006, v. 13, n. 13, p. 1037, doi. 10.1038/sj.gt.3302755
By:
- Schambach, A;
- Schiedlmeier, B;
- Kühlcke, K;
- Verstegen, M;
- Margison, G P;
- Li, Z;
- Kamino, K;
- Bohne, J;
- Alexandrov, A;
- Hermann, F G;
- von Laer, D;
- Baum, C
Publication type:
Article
A radiation-controlled molecular switch for use in gene therapy of cancer.
Published in:
Gene Therapy, 2000, v. 7, n. 13, p. 1121, doi. 10.1038/sj.gt.3301223
By:
- Scott, S D;
- Marples, B;
- Hendry, J H;
- Lashford, L S;
- Embleton, M J;
- Hunter, R D;
- Howell, A;
- Margison, G P
Publication type:
Article
Development of synthetic promoters for radiation-mediated gene therapy.
Published in:
Gene Therapy, 2000, v. 7, n. 6, p. 511, doi. 10.1038/sj.gt.3301116
By:
- Marples, B;
- Scott, S D;
- Hendry, J H;
- Embleton, M J;
- Lashford, L S;
- Margison, G P
Publication type:
Article
A novel dual function retrovirus expressing multidrug resistance 1 and O6-alkylguanine-DNA-alkyltransferase for engineering resistance of haemopoietic progenitor cells to multiple chemotherapeutic agents.
Published in:
Gene Therapy, 1999, v. 6, n. 8, p. 1489, doi. 10.1038/sj.gt.3300962
By:
- Jelinek, J;
- Rafferty, J A;
- Cmejla, R;
- Hildinger, M;
- Chinnasamy, D;
- Lashford, L S;
- Ostertag, W;
- Margison, G P;
- Dexter, T M;
- Fairbairn, L J;
- Baum, C
Publication type:
Article
Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O6-alkylguanine-DNA alkyltransferase.
Published in:
Gene Therapy, 1998, v. 5, n. 6, p. 842, doi. 10.1038/sj.gt.3300699
By:
- Chinnasamy, N;
- Rafferty, J A;
- Hickson, I;
- Lashford, L S;
- Longhurst, S J;
- Thatcher, N;
- Margison, G P;
- Dexter, T M;
- Fairbairn, L J
Publication type:
Article
Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O6-benzylguanine-resistant O6-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O6-alkylating agents in vitro.
Published in:
Gene Therapy, 1998, v. 5, n. 6, p. 835, doi. 10.1038/sj.gt.3300698
By:
- Hickson, I;
- Fairbairn, L J;
- Chinnasamy, N;
- Lashford, L S;
- Thatcher, N;
- Margison, G P;
- Dexter, T M;
- Rafferty, J A
Publication type:
Article

Found: 31

A phase I trial of lomeguatrib and irinotecan in metastatic colorectal cancer.

Fern spore extracts can damage DNA.

Dietary variables associated with DNA N7-methylguanine levels and O<sup>6</sup>-alkylguanine DNA-alkyltransferase activity in human colorectal mucosa.

Bacterial and mammalian DNA alkyltransferases sensitize Escherichia coli to the lethal and mutagenic effects of dibromoalkanes.

Low O6-alkylguanine DNA-alkyltransferase activity in normal colorectal tissue is associated with colorectal tumours containing a GC-->AT transition in the K-ras oncogene.

Exploring molecular mechanisms in chemically induced cancer: Complementation of mammalian DNA repair defects by a prokaryotic gene.

A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours.

A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer.

A phase I study of extended dosing with lomeguatrib with temozolomide in patients with advanced melanoma.

A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer.

Phase II study of SPI-77 (sterically stabilised liposomal cisplatin) in advanced non-small-cell lung cancer.

O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts.

Dose finding and O6-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies.

Differential radiosensitisation by ZD1839 (Iressa), a highly selective epidermal growth factor receptor tyrosine kinase inhibitor in two related bladder cancer cell lines.

Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum.

Heterogeneity of O6-alkylguanine DNA-alkyltransferase expression in human breast tumours.

Immunohistochemical analysis of expression and allelotype of mismatch repair genes (hMLH1 and hMSH2) in bladder cancer.

Expression of Ku70 correlates with survival in carcinoma of the cervix.

Effect of expression of the Escherichia coli nth gene in Saccharomyces cerevisiae on the toxicity of ionizing radiation and hydrogen peroxide.

Relationships between the Cytotoxic Effects of Restriction Endonucleases and Radiation on Mammalian Cells.

Development of a novel rapid assay to assess the fidelity of DNA double-strand-break repair in human tumour cells.

Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells.

Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenografts.

PON1 increases cellular DNA damage by lactone substrates.

Protection of committed murine haemopoietic progenitors against BCNU toxicity does not predict protection of primitive, multipotent spleen colony-forming cells - implications for chemoprotective gene therapy.

Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus.

A radiation-controlled molecular switch for use in gene therapy of cancer.

Development of synthetic promoters for radiation-mediated gene therapy.

A novel dual function retrovirus expressing multidrug resistance 1 and O<sup>6</sup>-alkylguanine-DNA-alkyltransferase for engineering resistance of haemopoietic progenitor cells to multiple chemotherapeutic agents.

Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O<sup>6</sup>-alkylguanine-DNA alkyltransferase.

Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O<sup>6</sup>-benzylguanine-resistant O<sup>6</sup>-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O<sup>6</sup>-alkylating agents in vitro.