Normal levels of soluble E-selectin, soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) decrease with age.

Nash, M. C.; Wade, A. M.; Shah, V.; Dillon, M. J.

sE-selectin, sICAM-1, sVCAM-1 and von Willebrand factor (vWF) were assayed in 238 samples in a longitudinal study of 81 normal children from 9.5 to 15.5 years old. Multilevel modelling was used to quantify changes with age, sE-selectin, sICAM-1 and sVCAM-1 all fell significantly over the age range (by 17%, 16%, and 10%, respectively). In contrast, levels of vWF were not age-dependent. Our findings highlight the need for age-matched controls when studying cell surface adhesion molecules in disease groups, and may imply developmental changes in expression of these molecules and their shedding from the cell surface.

VON Willebrand factor; LONGITUDINAL method; SELECTING the Computer System (Book); SELECTINS; CELL adhesion; CELL membranes

Clinical & Experimental Immunology, 1996, Vol 103, Issue 1, p167

0009-9104

Academic Journal

10.1046/j.1365-2249.1996.925616.x