Title: Pemphigoid gestationis: maternal sera recognize epitopes restricted to the N-terminal portion of the extracellular domain of BP180 not present on its shed ectodomain.
Authors: Sitaru, C.; Powell, J.; Shimanovich, I.; Jainta, S.; Kirtschig, G.; Wojnarowska, F.; Zillikens, D.
Abstract: Pemphigoid gestationis (PG) is an autoimmune subepidermal blistering disease associated with pregnancy and characterized by linear deposition of C3 and, less frequently, of immunoglobulin (Ig)G along the dermal-epidermal junction (DEJ). Complement-fixing circulating IgG autoantibodies to the DEJ in serum of PG patients are mainly directed to the 180-kDa bullous pemphigoid antigen (BP180), a transmembrane hemidesmosomal glycoprotein. BP180 consists of an intracellular N-terminal globular head, a transmembrane region, and a C-terminal ectodomain.
Subjects: PREGNANCY complications; AUTOIMMUNE diseases; AUTOANTIBODIES; BLISTERS; IMMUNOGLOBULIN G; GLYCOPROTEINS
Publication: British Journal of Dermatology, 2003, Vol 149, Issue 2, p420
ISSN: 0007-0963
Publication type: Academic Journal
DOI: 10.1046/j.1365-2133.2003.05427.x

Pemphigoid gestationis: maternal sera recognize epitopes restricted to the N-terminal portion of the extracellular domain of BP180 not present on its shed ectodomain.

Sitaru, C.; Powell, J.; Shimanovich, I.; Jainta, S.; Kirtschig, G.; Wojnarowska, F.; Zillikens, D.